Posted by Larry Hoover on October 30, 2004, at 8:40:40
In reply to Cholesterol metabolism ? Lar » raybakes, posted by tealady on October 29, 2004, at 21:19:47
> OK I looked up what is needed maybe in the pathways
> http://www.genome.jp/kegg/pathway/map/map00140.html
> "AND CLICKING on 1.14.15.6
> Oxidoreductases
> Acting on paired donors with incorporation of molecular oxygen
> With a reduced iron-sulfur protein as one donor, and incorporation
> of one atom of oxygen"
>
> so as well oxygen maybe I need iron-sulfur...there's that sulfur again!!!! (and iron)Oxygen is the second most reactive element of them all....more so than is chlorine (from electronegativity standpoint). Fire is an uncontrolled oxygenation chain reaction. Currently, the atmosphere contains about 17% oxygen. If it got up to 22%, it would be impossible to put out fires with water (itself burned hydrogen), as the exothermic reactions would not be cooled enough by the heat absorption capacity of water (specific heat), and the latent heat of vapourization.
The point is, our bodies work only because Mother Nature has learned how to slow fire down, to control it somewhat. Sulphur loves oxygen. Oxidative stress depletes sulphur compounds in the body.
> OK so for sulfur I need TMG, NAC, NAG ??
TMG remethylates one particular sulphur compound, homocysteine, but it is not a source of sulphur.
Common sulphur sources are methionine, SAMe, cysteine, taurine, creatine (a tripeptide with methionine). NAC is N-acetyl-cysteine, so it is a source. MSM too.
> I guess something like magnesium sulfate is different?? I have epsom salt baths but they always make me very tired after..actually usually drift in and out of sleep in the bath. Note sure if that's the sulfates or just the relaxation.
More likely the magnesium. It is taken in transcutaneously, though only slightly. Sulphates are not a good metabolic source of sulphur, as they're already fully oxidized (SO4--).
>
> Lar mentioned sulfur stuff to me last year too re thyroid hormones.
>
> Another cholesterol path
> http://www.genome.jp/kegg/pathway/map/map00120.html
> needs that NADPH again and oxygen
> "With NADH or NADPH as one donor, and incorporation of one atom of
> oxygen"
>
>
> I thought that CoQ10 (ubiquinone) should be somewhere around cholesterol too? as the drugs that inhibit cholesterol synthesis also stop CoQ10 synthesis? But I can't find the link there.
>
> JanThe statin drugs do block CoQ10. That may be the mechanism of some of the side effects. You're likely going to see recommendations to supplement CoQ10 with statin drugs.
Lar
poster:Larry Hoover
thread:359642
URL: http://www.dr-bob.org/babble/alter/20041022/msgs/409092.html