Posted by raybakes on October 28, 2004, at 7:57:18
In reply to Re: Help needed with cholinergic drug reactions? » raybakes, posted by tealady on October 27, 2004, at 22:34:20
Hi Jan - meant to be decorating today and avoiding the computer...but couldn't resist looking up this link...
Austistic children have problems maintaining their sulphate levels, and so have problems detoxifying. They also have problems digesting because the hormone CCK needs sulphate to activate it. CCK is needed for the release of vasopressin and oxytocin.
Dose response of arginine vasopressin to the CCK-B agonist pentagastrin.
Abelson JL, Le Melledo J, Bichet DG.
University of Michigan Department of Psychiatry, Anxiety Disorders Program, Ann Arbor, MI, USA.
Cholecystokinin (CCK) is a peptide neurotransmitter that modulates hypothalamic-pituitary-adrenal (HPA) axis activity and may be involved in fear or anxiety states. Arginine vasopressin (AVP) also modulates HPA axis activity and may play a role in fear conditioning. Few human studies have examined interactions between CCK and AVP systems. To explore relationships between CCK-B receptor activation, the HPA axis response, and AVP release, a dose-response study using the CCK-B receptor agonist pentagastrin was conducted. Adrenocorticotropin (ACTH) and cortisol results have been previously reported and AVP data is presented here. Thirty-five healthy subjects were randomly assigned to receive placebo, or 0.2, 0.4, 0.6, or 0.8 microg/kg doses of pentagastrin. AVP release appeared to increase with increasing doses of the CCK-B agonist. However, this may have been due to a greater percentage of subjects releasing AVP in the higher dose groups, rather than a direct effect of dose on magnitude of response. AVP and ACTH responses were correlated, but AVP response alone could not account for the magnitude of the ACTH response. AVP release was significantly correlated with anxiety symptom responses. These findings suggest a possible role for the CCK-B receptor in AVP release, which may be at least partially separate from its role in modulation of the HPA axis. Further work is needed to determine whether these are physiologically meaningful interactions and to determine their functional implications
poster:raybakes
thread:359642
URL: http://www.dr-bob.org/babble/alter/20041022/msgs/408282.html