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VitD3 » raybakes

Posted by tealady on October 4, 2004, at 3:21:47

In reply to Re: Supplements for brain fog? » karaS, posted by raybakes on October 2, 2004, at 14:40:04

> Just came across this to do with autoimmune disease, particularly hashimoto's. Seems a genetic error in vitamin d production is common in hashimoto's.
>
> So low glutathione, low vitamin D and high prolactin are common in autoimmune disease. Interesting that prolactin is high in autism too, and as ritalin increases dopamine, wonder whether attention deficit kids have autoimmune problems?
>
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15296474

this seems to say that thera re probably other enzymes that do the conversion to VitD3..so maybe no worries there?
"This idea may be supported by previous findings that complete loss of 1(OH)ase activity by genetic mutation of the 1(OH)ase gene in humans did not cause a reduction in serum 1,25(OH)2D3 levels sufficient to cause severe rickets (5, 6). It is therefore likely that, at least in humans, enzyme(s) other than 1(OH)ase (CYP27B1) are also specifically or nonspecifically responsible for 1,25(OH)2D3 production."
http://endo.endojournals.org/cgi/content/full/142/7/2734
Jan


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