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Re: Neuroleptic weight gain dose dependend? Linearly?

Posted by undopaminergic on January 5, 2021, at 7:50:47

In reply to Re: Neuroleptic weight gain dose dependend? Linearly?, posted by Lamdage22 on January 4, 2021, at 10:31:59

> Is the weight gain caused by histamine antagonism?

That's how I understand it. If nothing else, it is sedative and stimulates appetite. Perhaps through a general sedative effect, it lowers the rate of metabolism, but I'm no expert on it. The more awake, excited, and active you are, the faster you burn calories. That's how exercise and stimulants work to lose weight.

> Thanks. Do I understand it correctly, that I don't see as much of a weight gain reduction until I reach lowerish doses? 800 or 1000 doesn't make much of a difference, but 600 or 400 does more so?

Yes, if my assumptions are correct.

It occurs to me now, that if I were you, I would probably experiment with low-dose (0.5--2 mg) flupenthixol, as it has been shown to have an antidepressant as well as antipsychotic effect. Another interesting possibility is beta2-adrenergic agonists for weight loss; they increase blood-flow to muscles, and probably for that reason, they are somewhat anabolic. They increase pulse, but are actually good for the heart (even better than beta1-antagonists), perhaps because the heart is a muscle and will benefit from enhanced perfusion.





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