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Re: Neuroleptic weight gain dose dependend? Linearly?

Posted by undopaminergic on January 4, 2021, at 10:18:03

In reply to Re: Neuroleptic weight gain dose dependend? Linearly?, posted by Lamdage22 on January 4, 2021, at 9:10:49

> So would you say the weight gain is linearly dose dependent?

As I said in my first reply, no, I don't think it is linear -- I think the dose-response curve flattens with higher doses. To illustrate what I mean, let's say 25 mg achieves 33% central histamine H1 blockade, 50 mg achieves 50%, 100 mg does 75%, 150 mg 85%, and 200 90%, 500 mg 95%, 1000 mg 98%, etc.

Note that the numbers are just taken out of the air, but I think you see what I mean.

It's the same with methylphenidate and dopamine transporter transporter blockade.

I have a prescription of just 25 mg as needed for sleep! It's hard to believe such a dose would do anything, but I imagine the doctor has experience suggesting otherwise... or she wouldn't have prescribed it.





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