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Re: Neuroleptic weight gain dose dependend? Linearly?

Posted by undopaminergic on January 5, 2021, at 8:56:21

In reply to Re: Neuroleptic weight gain dose dependend? Linearly?, posted by Lamdage22 on January 5, 2021, at 8:04:08

> I think it is 5ht2c antagonism that produces weight gain.

5-HT2C antagonism enhances dopamine release. I don't see why that would lead to weight gain, but on another note, 5-HT2C *agonism* is probably the mechanism through which SSRIs induce apathy. And despite this agonism, SSRI are known not infrequently to produce weight gain, especially paroxetine.

Anyway, as far as I've been able to determine, there are no good (ie. reasonably potent and selective) 5-HT2C antagonists clinically available. I've tried agomelatine and sertindole, but noticed no benefit, and I had to quit the sertindole because it clogged up my nasal passages like nothing I'd ever experienced before.





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