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Re: Neuroleptic weight gain dose dependend? Linearly?

Posted by undopaminergic on January 4, 2021, at 7:33:48

In reply to Re: Neuroleptic weight gain dose dependend? Linearly?, posted by Lamdage22 on January 4, 2021, at 6:55:58

> I like how tiaprid sounds. The sulpirides, nah, please no Tardive Dyskinesia!

What makes you think "sulpirides" are particularly liable to induce TD? Seems the opposite to me, based on eg:
cite: "Sulpiride differs pharmacologically in several respects from conventional neuroleptics, and has not been convincingly shown to cause tardive dyskinesia. Among currently available treatments, it may therefore be considered a drug of choice for treatment of tardive dyskinesia.".

That said, I also saw a case report suggesting amisulpride at a low dose caused TD.

In any case, someone mentioned here that even clozapine can cause TD, so *no* neuroleptic is totally safe in this respect. This includes quetiapine (Seroquel); one case report is entitled "Early-onset tardive dyskinesia in a neuroleptic-naive patient exposed to low-dose quetiapine.".

> Is Tiaprid less harmful metabolically than Seroquel?

Of course. It's hard to find something delivering such a powerful dysmetabolic "punch" in exchange for such a low antipsychotic efficacy.

> How sedating is it? Will a high dose put me to sleep?

Almost certainly not. The benzamides are very "clean" in that they don't affect a multitude of non-targeted receptors such as histamine or acetylcholine. For some reason, although dopamine is crucial in promoting wakefulness, dopamine antagonists do not seem to induce sleepiness, although I'm sure it can happen in some cases. So, if you're looking for a hypnotic, stay with Seroquel.





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