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Re: Neuroleptic weight gain dose dependend? Linearly?

Posted by undopaminergic on January 4, 2021, at 6:47:09

In reply to Neuroleptic weight gain dose dependend? Linearly?, posted by Lamdage22 on January 3, 2021, at 6:41:42

> Hey guys,
> Im 210 and not tall (but some muscle), but yeah, I really hope to lose some weight. I have been reducing Seroquel from 1000 to currently 650 in a period of two years. I want to almost eliminate Seroquel Prolong during daytime. I have handled the last reduction from 700 to 650 better than expected. Maybe I can go 600 soon.
> Can I expect the weight gain effects to lessen linearly with reduction of dosage?

Does Seroquel block central histamine H1-receptors linearly with dose? I'm thinking the dose-response curve flattens with increasing dose.

Seroquel is a poor anti-psychotic, so if it is the neuroleptic aspect that keeps you from reducing the dose faster, you could advantageously replace it with any of a number of agents that have a higher ratio of dopamine/serotonin to histamine blockade. Personally, I'd go with a benzamide, ie. amisulpride or sulpiride (maybe tiapride too).





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