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Re: Why does Mirtazapine cause Restless Legs Syndrome?

Posted by undopaminergic on June 27, 2020, at 1:29:52

In reply to Re: Why does Mirtazapine cause Restless Legs Syndrome? undopaminergic, posted by Skeletor on June 26, 2020, at 16:09:53

> > >
> > > BUT opioids induce histamine release, so it could just be a histamine thing?
> >
> > Some opioids, including morphine, induce the release of histamine from mast cells, which may lead to itching, but (AFAIK) they don't release histamine in the CNS.
> >
> > -undopaminergic
> >
> Does it need to cross the blood brain barrier or could it stimulate "it" directly in the legs?

Mast cells exist in peripheral tissues including, in particular, the skin, so it could affect the legs. However, this would more likely cause itching than RLS.





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