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Re: Why does Mirtazapine cause Restless Legs Syndrome?

Posted by undopaminergic on June 27, 2020, at 1:29:52

In reply to Re: Why does Mirtazapine cause Restless Legs Syndrome? undopaminergic, posted by Skeletor on June 26, 2020, at 16:09:53

> > >
> > > BUT opioids induce histamine release, so it could just be a histamine thing?
> >
> > Some opioids, including morphine, induce the release of histamine from mast cells, which may lead to itching, but (AFAIK) they don't release histamine in the CNS.
> >
> > -undopaminergic
> >
>
> Does it need to cross the blood brain barrier or could it stimulate "it" directly in the legs?
>

Mast cells exist in peripheral tissues including, in particular, the skin, so it could affect the legs. However, this would more likely cause itching than RLS.

-undopaminergic


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URL: http://www.dr-bob.org/babble/20200511/msgs/1111038.html