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Re: Why does Mirtazapine cause Restless Legs Syndrome? » undopaminergic

Posted by Skeletor on June 26, 2020, at 16:09:53

In reply to Re: Why does Mirtazapine cause Restless Legs Syndrome?, posted by undopaminergic on June 24, 2020, at 15:34:20

> >
> > BUT opioids induce histamine release, so it could just be a histamine thing?
>
> Some opioids, including morphine, induce the release of histamine from mast cells, which may lead to itching, but (AFAIK) they don't release histamine in the CNS.
>
> -undopaminergic
>

Does it need to cross the blood brain barrier or could it stimulate "it" directly in the legs?


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poster:Skeletor thread:1110839
URL: http://www.dr-bob.org/babble/20200511/msgs/1111027.html