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Re: Why does Mirtazapine cause Restless Legs Syndrome? ed_uk2010

Posted by linkadge on June 21, 2020, at 8:01:05

In reply to Re: Why does Mirtazapine cause Restless Legs Syndrome?, posted by ed_uk2010 on June 20, 2020, at 8:55:42

>It's due to the alpha-2 NE antagonism.

I concur with this. Alpha-2 antagonists can augment dopamine blockers in the treatment of schizophrenia. Combining alpha-2 antagonism and d2 antagonism can result in antipsychotic effects with a lower degree of d2 blockade. This suggests that alpha-2 antagonists may have a dopamine lowering effect (at least in certain brain regions).




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