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Re: Why GABA works

Posted by alchemy on June 22, 2020, at 20:08:14

In reply to Re: Why GABA works, posted by undopaminergic on June 22, 2020, at 0:56:17

Has anyone been successful taking the supplement long term? I've read Amazon experiences and it makes me weary. Something is wrong with my GABA (over simplified). I feel some happiness with alcohol (don't drink anymore) and ambien. The more I study the body, the more complicated it gets. Some of my notes:

GABRB2 (one of the GABA genes): A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. Functions also as histamine receptor and mediates cellular responses to histamine (By similarity). Decrease IL8 secretion?

Clinical depression can sometimes be caused by hypothyroidism.[54] Some research[55] has shown that T3 is found in the junctions of synapses, and regulates the amounts and activity of serotonin, norepinephrine, and GABA in the brain.

We also identified genes with associated medications which, although not aimed at treating depression, may provide unpredicted drug benefits or adverse effects for those with the disorder. The Neuregulin 1 (NRG1) receptor ErbB4, found on GABAergic neurones, has been identified as a potentially druggable target for depression, anxiety and schizophrenia.

Related to the gut - LPS also inhibits the activity of GABA and GLT-1/EAAT2 in the central nervous system (CNS), thus causing problems with glutamate-induced excitotoxicity.

Ligand-gated ion channels are likely to be the major site at which anaesthetic agents and ethanol have their effects...In particular, the GABA and NMDA receptors are affected by anaesthetic agents at concentrations similar to those used in clinical anaesthesia.

Some SNPs in the GABRA2 gene has been linked to Alcoholism.




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