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Why GABA works

Posted by linkadge on June 14, 2020, at 15:44:21

Although GABA purportedly does not cross the blood brain barrier (BBB), I have come up with a few explanations for why it works.

1) Gut bacteria can convert GABA into ketones which do cross the BBB and affect mood

2) Immune cells in the blood have gaba receptors which, when activated, systemic inflammation. These inflammatory mediators can pass from the blood to the brain. Hence, reducing systemic inflammation may, in turn, decrease brain inflammation.

Again, these are just theories, but may in part explain why so many people report that GABA does have an effect.





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