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Re: Why GABA works

Posted by undopaminergic on June 22, 2020, at 0:56:17

In reply to Re: Why GABA works undopaminergic, posted by linkadge on June 21, 2020, at 8:25:41

> This hypothesis has been around for a while. Originally the anticholinergic properties of TCAs were thought to be side effects. More recently (with the confirmation of the antidepressant effect of scopolamine) it is apparent that blocking acetylcholine can itself have antidepressant properties.

Right. This could be part of the antidepressant mechanism of trimipramine (which I'm currently using).

On another note, have you looked into central histamine H2-receptor modulators? Trimipramine is an antagonist. Another antagonist, famotidine, has shown promise for the treatment of negative symptoms of schizophrenia. Therefore, this class of drugs could treat the same symptoms in depression or parkinsonism.

> In animal models, increasing stress leads to an increased sensitivity of muscarinic receptors. This may be an adaptive mechanism (i.e. increased cholinergic output to try and understand / process the stressor). The 'flinders sensitive line' of mice also appears to be supersensitive to acetylcholine.

Rats. I think that is what I seem to be (mis)remembering. Maybe this very article:
Title: "Blunted Response to Cocaine in the Flinders Hypercholinergic Animal Model of Depression"
Note that the article doesn't seem particularly interesting.

> They may also be anti-manic (by reducing dopamine release).

That is interesting.

> For me, depression is when my thinking becomes trapped. I tend to overthink, and/or think way too 'big picture'. The future seems hopeless and and cannot find any moments of peace.

Have you tried meditation?

> I bough some belladonna extract (tincture). You have to be VERY careful with this stuff. ONE drop needs to be diluted!! But, basically if I get to a place where I simply become incapacitated, I use this. It seems to dramatically reduce the 'emotional overtone', to where I return to being 'here'.
> I sometimes use it with marijuanna (which too can be anticholinergic), but again, you need to be very careful. You can get very try mouth and tachycardia.

With higher doses, you can also get a delirious trip, which is very realistic. The experiences (trip reports) on Erowid are interesting.





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