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Re: 'safer' not 'better'? linkadge

Posted by SLS on May 13, 2020, at 18:43:08

In reply to Re: 'safer' not 'better'? SLS, posted by linkadge on May 13, 2020, at 7:52:51

Wow, Linkadge! Great work. I like how much you are able to say in so few words. Very concise and efficient. Have you ever considered writing? I didn't know there were subtypes of the GABA-A receptor. Makes sense. How many are there?

Are you still feeling better?


- Scott

> There seems to be evidence that gaba-a dysregulation is present in post-partum depression (and perhaps anxious, melancholic depression). However, only certain gaba subtypes are associated with mood regulation (as opposed to anticonvulsant, amnesic, muscle relaxant, and anxiolytic effects).
>
> Reading up on CBD (also a positive allosteric modulator of GABA-a) it seems to increase the effects of the two gaba-a subtypes that are dysregulated in bipolar. I don't remember these off hand, but I believe one of them was the gamma subtype.
>
> Some depression, however, is likely associated with a predominance of gaba (relative to glutamate). Gaba antagonists are generally considered 'stimulant' and 'pro-cognitive' (and there appears to be a gaba excess in certain disorders like Alzheimer's. Of course, too much gaba antagonism and you have a seizure.
>
> Linkadge
>
>


Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.

 

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poster:SLS thread:1109960
URL: http://www.dr-bob.org/babble/20200511/msgs/1110094.html