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Re: 'safer' not 'better'? SLS

Posted by linkadge on May 13, 2020, at 7:52:51

In reply to Re: 'safer' not 'better'?, posted by SLS on May 12, 2020, at 21:00:29

There seems to be evidence that gaba-a dysregulation is present in post-partum depression (and perhaps anxious, melancholic depression). However, only certain gaba subtypes are associated with mood regulation (as opposed to anticonvulsant, amnesic, muscle relaxant, and anxiolytic effects).

Reading up on CBD (also a positive allosteric modulator of GABA-a) it seems to increase the effects of the two gaba-a subtypes that are dysregulated in bipolar. I don't remember these off hand, but I believe one of them was the gamma subtype.

Some depression, however, is likely associated with a predominance of gaba (relative to glutamate). Gaba antagonists are generally considered 'stimulant' and 'pro-cognitive' (and there appears to be a gaba excess in certain disorders like Alzheimer's. Of course, too much gaba antagonism and you have a seizure.





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