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Re: 'safer' not 'better'? SLS

Posted by undopaminergic on May 14, 2020, at 2:50:02

In reply to Re: 'safer' not 'better'? linkadge, posted by SLS on May 13, 2020, at 21:05:14

> My first reaction to learning of the actions of zuranolone and brexanolone was to wonder if increasing GABA-A might quell the overactivity in the lateral habenula or the ventral tegmental area observed in depression. However, I found this:
>
> https://stm.sciencemag.org/content/6/234/234ec76
>
> https://science.sciencemag.org/content/344/6181/313.abstract?_ga=2.171616032.1625245966.1589419290-1749848103.1589419290
>

The part about hyperexcitable dopamine neurons in depression sounds confusing and hard to believe, because dopaminergic stimulants *ameliorate* depression and they *boost* the effects of VTA activity in the nucleus accumbens, and they helps against apathy.

On a slightly other note, this article seems to be about a mouse model of depression, which is hardly the same syndrome as in human depression.

-undopaminergic


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URL: http://www.dr-bob.org/babble/20200511/msgs/1110109.html