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Re: What do TRD patients take without an MAIO linkadge

Posted by undopaminergic on December 11, 2019, at 10:37:00

In reply to Re: What do TRD patients take without an MAIO, posted by linkadge on December 10, 2019, at 15:38:36

> Just to add, Ritalin may also act via a 5-ht related mechanism. A metabolite of Ritalin acts as a 5-ht1a agonist. 5-ht1a agonists (like buspirone) can also reduce hyperactivity (but perhaps not improve cognition to the same degree).
> Linkadge

That is a new piece of knowledge about Ritalin to me. In any case, I have read that activation of 5-HT1A is pro-dopaminergic (opposite to 5-TH2C). These facts almost certainly also play an important role in the pharmacology of SSRIs.





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