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Re: What do TRD patients take without an MAIO linkadge

Posted by undopaminergic on December 10, 2019, at 12:41:16

In reply to Re: What do TRD patients take without an MAIO, posted by linkadge on December 9, 2019, at 17:26:32

> The catechins in cocoa are MAO inhibitors (more selective to MAO-B).
>

And the catechins in green tea are COMT inhibitors?

It would be interesting to combine them.

What about bioavailability of these substances? I read green tea catechins are poorly absorbed.

> I've felt that the combination of a MAO-B inhibitor and a NET inhibitor would be particularly good for cognitive problems.
>

Reboxetine on selegiline was rather unpleasant in my experience. I have reason to believe I may have excessive levels of noradrenaline. I also did not fare well on mirtzapine, which increases noradrenaline release by blocking alpha2-adrenergic autoreceptors. I almost got some kind of cramps in my neck (I do not recall clearly).

> Cocoa (and coffee) also contain beta carbolines which are MAOIs (more selective towards MAO-A).
>

Tobacco too, it seems:
https://en.wikipedia.org/wiki/Harmala_alkaloid

> The beta carbolines are also benzodiazepine antagonists (can increase anxiety).
>

That's news to me. Good to learn something.

> I believe the beta carbolines were originally identified as the first endogenous benzodiazepine antagonists. There is another endogenous compound called isatin which is both a MAOI and a benzodiazepine receptor antagonist. It is released during stress (I presume to give a quick fight / flight response).
>

Interesting. Apparently it (isatin) is a metabolite of adrenaline.

> If you gave me 10-20 mg of PEA in a capsule and an identical placebo, I could identify the PEA 100% of the time. The problem is that the effects are fairly short lasting. However, if I use the energy boost to get exercising, it can help improve mood for a longer duration.
>

How often do you take it? Is there any tolerance?

-undopaminergic


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