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Re: What do TRD patients take without an MAIO linkadge

Posted by undopaminergic on December 11, 2019, at 9:17:04

In reply to Re: What do TRD patients take without an MAIO, posted by linkadge on December 10, 2019, at 15:06:45

I realised this after I had already posted.

> Absence of MPTP-induced neuronal death in mice lacking the dopamine transporter.
>
> https://www.ncbi.nlm.nih.gov/pubmed/10072302
>
> Dopamine transporter is required for in vivo MPTP neurotoxicity: evidence from mice lacking the transporter.
>
> https://www.ncbi.nlm.nih.gov/pubmed/9282960
>
> Linkadge

Yes.

Before looking, I knew I would find an article like this:
https://www.ncbi.nlm.nih.gov/pubmed/3875884
"Cocaine blocks the dopamine depletion induced by MPTP."

Selegiline (l-deprenyl) also prevents MPTP toxicity but I have trouble finding a succinct abstract. Likewise do other MAOIs (such as tranylcypromine) that inhibit MAO-B.

-undopaminergic


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