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Re: What do TRD patients take without an MAIO

Posted by linkadge on December 9, 2019, at 17:26:32

In reply to Re: What do TRD patients take without an MAIO linkadge, posted by undopaminergic on December 9, 2019, at 9:36:36

The catechins in cocoa are MAO inhibitors (more selective to MAO-B). They also have some monoamine reuptake effects (more selective for norepinephrine). I've felt that the combination of a MAO-B inhibitor and a NET inhibitor would be particularly good for cognitive problems.

I'm not sure what degree of MAO-B inhibition one would get through regular chocolate consumption, but polyphenols like catechin can build up in the system over time.

Cocoa (and coffee) also contain beta carbolines which are MAOIs (more selective towards MAO-A). The beta carbolines are also benzodiazepine antagonists (can increase anxiety). I believe the beta carbolines were originally identified as the first endogenous benzodiazepine antagonists. There is another endogenous compound called isatin which is both a MAOI and a benzodiazepine receptor antagonist. It is released during stress (I presume to give a quick fight / flight response).

If you gave me 10-20 mg of PEA in a capsule and an identical placebo, I could identify the PEA 100% of the time. The problem is that the effects are fairly short lasting. However, if I use the energy boost to get exercising, it can help improve mood for a longer duration.

Linkadge


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