Posted by CaptainAmerica1967 on January 5, 2012, at 9:25:45
In reply to Re: grief and major depression » CaptainAmerica1967, posted by SLS on December 31, 2011, at 6:44:24
Sorry, I missed this one Scott. I'm not sure what you mean by this question but I know that dynorphins work through Kappa receptors by Kappa binding dynorphins. One of the first symptoms I experienced at the age of 16 with anxiety, depression was a decreased libido and that might mean low dopamine as dopamine is the libido enhancing neurotransmitter besides PEA (phenylethylamine, short acting like in chocholate or long lasting increase of PEA by taking deprenyl-selegiline; also enhances brain longevity by increasing SOD, one of the bodies main antioxidants-rats lived almost twice as long on selegiline. I took selegiline while in college and couldn't foucs on studying as my libido was through the roof and would always be staring at various ladies in class instead of listening to the professor). Anyways, dynorphins decrease libido somehow via Kappa receptors binding. Oxytocin which is being studied as an antidepressant and is the cuddle love hormone (when in love) is associated somehow with dynorphins decreasing oxytocin via A negative feedback loop. Most of my life I took Nardil (I'm quite sure I lack GABA production produced in the nucleaus accumbens which also is the focus of deep brain stimulation and the area around Broadmanns 25-Helen Mayberg, MD, for depression, again an overactive brain) and MAOIs in general via the liver decrease testosterone production which further can cause depression and decreased libido (I think Nardil increases prolactin as well which inhibit libido) except until several year ago when I switched to Parnate which also decreases testosterone but the increase in dopamine from prevention of being broken down may counteract the liver decrease in testosterone. By the way, Buprenorphine and all opioids (heroin) decrease testosterone as well as lithium, haldol, marijuana, and barbiturates. My total tesstosterone (249-836) is very low normal being 252 (I'm 5' 11", 240 pounds, very low fat so little chance of conversion to estrogen and I lift weights and take 1000 IU of vitamin D which both are suppose to increase testosterone but mine is still low. It's really the "free testosterone" that has the benefits on the body; decrease c-reactive protein, cardiovascular disease, decrease in strokes, as well as decrease in osteoporosis, bone fracture, type 2 diabetes, metabolic disorder, sleep apnea, libido and other things like mood but most physicians including mine aren't very savvy when doing blood screening tests. OK, sorry, I got off the subject of dynorphins. So maybe Kappa antagonists block dynorphins as well to produce the antidepressant and antianxiety effect. I can say without a doubt that buprenorphine is a much better antianxiety medication than any type of benzodiazepine I've tried but maybe my anxiety is a subtype as describe in some literature on kappa antagonist. Lastly, I also first noticed feeling extremely warm and hot all the time like hot flashes but my thyroid tests were normal and I just looked this up and saw some correlation with body temperature and dynorphins.
poster:CaptainAmerica1967
thread:81414
URL: http://www.dr-bob.org/babble/20111226/msgs/1006407.html