Posted by SLS on December 31, 2011, at 6:44:24
In reply to Re: grief and major depression, posted by CaptainAmerica1967 on December 22, 2011, at 2:56:03
Wow. You are one smart dude!
Do opioid kappa receptors recognize dynorphins?
- Scott
> I think there are an whole array as we already know of division and subdivision of major depresssive disorders (unipolar, atypical unipolar, bipolar I and II, major depression association with temporal lobe epilepsy, major depression mixed sleep disorders and to many more to list).
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> Psychosocial factors such as a loss or PTSD from loss of a witnessing a parent at an early age could come into play into developing a disorder.
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> Also, genetic can play a prominent role as we know.
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> The number of treatments are phenomenal from typical psychopharmacology (Ivan Goldberg, MD has complied a good list on his website; http://www.psycom.net/depression.central.drugnames.html. I've taken almost every single one.
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> Other biological treatments like the "Gold Standard" doesn't work for everyone as I had it right after high school in 1985 and into 1985 for a whopping 70 something treatments with no effect.
> The only biological treatments that helped me went I wasn't be ridden was hard physical exericise to where I sweat well. Exercise is known to affect all the major mood bolstering neurotransmitters but in addition affect/effect the natural opiates and the receptors something that none of the currently available antidepressants do except the tricyclics but only for pain or the mu receptors not against dynorphins which make you feel sluggish worn down, the opposite, enkephalins and endorphins so my psychiatrist by exercise said he had others that only get a great repsonse from physical exercise and used buprenorphine with them and so he tried me on sublinginual buprenorphine and for the first time since I was 15y/o and two years ago went I tried buprenorphine(Subutex-no naloxone). I had forgotten how good life can really feel normal and functional all the time; interesting paper I read about the gout medication allopurinal is that it too has "anatagonist activity a the kappa opioid receptors but is very weak but so is buprenorphine and why so many other drug companies are working on "specific kappa receptors antagonists/blockers that would probably made one feel a lot better than just a partial kappp antongist(go to http://en.wikipedia.org/wiki/Kappa_Opioid_receptor(all that time I could have done even better in high school and college; maybe went on further, dated "a lot" as that was last on my mind and a guilty feeling let down my sports teammates a star football player, promising state championship wrestler as I had gone to wrestling champ down in Pennsylvania at Lock Haven after having a great sophomore year and explovsive sprinter and shot putter. We all have our guilt on what we might have been able to do if I hadn't be the the horrific, dreadful, life altering mood disoders of various types of depression.
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> Other biological therapies, I guessing because I read the brain is way overactive compared to non depressed patienet (more blood flow/more glucose being used; I had to read a paragraph twice sometines to capture all of it) that the bioligical treatment sleep depreviation which was one of the only treatments for depression prior to pharmacotherapy and ECT. I also read studies by the National Institute of Mental Health that cold water therapy use two-three times a day is effectiive antidepressant calming the overactive brain afterward increasing levels of endorphins and norepinephine from the locus cereuleau brain structure deep in the brain also associate with panic attacks by releasing to much and the cold shower desensitizes the LC and ehanches enodorphin production.
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> As far a my "grief" in life, yes, I got over the loss of my parents and other relatives at an early age and over the bad feelings that this was a daily lifelong struggle I would have to survive as I would attack it the best way I knew and that is with physical exercise, meditation, medications and "HOPES" for the future like once neurosurgeons and neurologist get the Dee Brain Stimulation down to a "T" in having know exactly where to place the stimulant electrodes for specific types of depresion, but there is always a risk with survery.
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Some see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:81414
URL: http://www.dr-bob.org/babble/20111226/msgs/1005971.html