Posted by sigismund on October 21, 2010, at 2:09:50
In reply to Re: Agomelatine » sigismund, posted by SLS on October 20, 2010, at 14:54:02
>How would you describe the quality of your therapeutic response to agomelatine? Are you still taking it? Is 12.5mg as effective for you as 25mg?
My guess, Scott, is that ago will only be a little useful to you and that it might make sense to restrict your hopes to some improvement in sleep and a bit of dopaminergic push.
My response has changed over time. I have taken it for a year or two in doses that have ranged from 12.5mg/d to 50mg/d.
The initial response was impressive, by which I mean that I liked it and other people remarked that I was looking better.
Sleep was greatly improved......I slept normally.So what happened? (I mean with the sleep).
I don't know. I have a theory that my consumption of baicall skullcap (which I need for allergies) inhibits the enzyme which metabolises ago leading to higher concentrations of it, leading to tolerance of some of the effects, leading to bad sleep again. I still feel the dopaminergic thing.I'm currently on 25mg.
12.5 would not be as effective but it would not be a problem lowering it.
There seems to be little or no discontinuation syndrome.I don't have much experience with ADs. Only a little Parnate, tianeptine, agomelatine and the alternative things. If things got bad for me I'd try Nardil.
It's pathetic we know so little about sleep, and a pity the options are not better.
I went to ask a patient to look at Trazodone (some libido or more likely capacity wouldn't hurt) but it sounded so weird and awful I wasn't keen to try it.
poster:sigismund
thread:966212
URL: http://www.dr-bob.org/babble/20101020/msgs/966445.html