Posted by Bob on October 21, 2010, at 1:20:44
In reply to Re: Stablon (tianeptine), posted by SLS on October 20, 2010, at 5:29:21
> > Yes Scott, I remember reading a post where you were having problems with Parnate. I am interested to hear what is working for you at the moment.
>
> I added agomelatine (Valdoxan) to my regime. The antidepressant effect is currently mild at best. However, it is early. I have been taking agomelatine for only 10 days. I wouldn't want to guarantee what it is about this drug that allows it to exert an antidepressant effect. For now, it seems that melatonin M1 and M2 receptor stimulation and serotonin 5-HT2c blockade are both important as per elegantly designed studies.
>
> I would like to give things another 2-4 weeks to measure the degree and persistence of the treatment adjustment. I am currently taking 25mg. As per the manufacturer's instructions, I will raise the dosage to 50mg after 2 weeks should the improvement plateau or wane.
>
> Current treatment regime:
>
> Nardil 90mg
> nortriptyline 150mg
> Lamictal 200mg
> agomelatine 25mg
>
> It turns out that the only other person I know of for whom agomelatine is producing a robust therapeutic response is also taking Nardil 90mg.
>
> I have been losing sleep because of the sleep disruptions agomelatine is known to produce early in treatment. I have been moderately sleep deprived for a few days. It is possible that this is what is responsible for the mild improvement I am now experiencing. For some people, sleep deprivation can induce a transient antidepressant effect. It can even precipitate mania in certain individuals.
>
> I am cautiously optimistic. If the current improvement persists for longer than 3 days, I will become less cautious in my optimism.
>
> Crossed-fingers, well wishes, and prayers for me are welcome.
>
> :-)
>
>
> - Scott
>
I'm pullin' for you and everyone else on this board. I'd love to hear about a novel drug like Valdoxan making a difference. Please keep us apprised.- Bob
poster:Bob
thread:966212
URL: http://www.dr-bob.org/babble/20101020/msgs/966441.html