Posted by SLS on October 20, 2010, at 5:29:21
In reply to Re: Stablon (tianeptine), posted by bearfan on October 19, 2010, at 21:19:26
> Yes Scott, I remember reading a post where you were having problems with Parnate. I am interested to hear what is working for you at the moment.
I added agomelatine (Valdoxan) to my regime. The antidepressant effect is currently mild at best. However, it is early. I have been taking agomelatine for only 10 days. I wouldn't want to guarantee what it is about this drug that allows it to exert an antidepressant effect. For now, it seems that melatonin M1 and M2 receptor stimulation and serotonin 5-HT2c blockade are both important as per elegantly designed studies.
I would like to give things another 2-4 weeks to measure the degree and persistence of the treatment adjustment. I am currently taking 25mg. As per the manufacturer's instructions, I will raise the dosage to 50mg after 2 weeks should the improvement plateau or wane.
Current treatment regime:
Nardil 90mg
nortriptyline 150mg
Lamictal 200mg
agomelatine 25mgIt turns out that the only other person I know of for whom agomelatine is producing a robust therapeutic response is also taking Nardil 90mg.
I have been losing sleep because of the sleep disruptions agomelatine is known to produce early in treatment. I have been moderately sleep deprived for a few days. It is possible that this is what is responsible for the mild improvement I am now experiencing. For some people, sleep deprivation can induce a transient antidepressant effect. It can even precipitate mania in certain individuals.
I am cautiously optimistic. If the current improvement persists for longer than 3 days, I will become less cautious in my optimism.
Crossed-fingers, well wishes, and prayers for me are welcome.
:-)
- Scott
The measure of achievement lies not in how high the mountain,
but in how hard the climb.The measure of success lies only in how high one feels he must
climb to get there.
poster:SLS
thread:966212
URL: http://www.dr-bob.org/babble/20101020/msgs/966337.html