Posted by linkadge on February 20, 2006, at 13:42:01
In reply to Re: NRIs are infact dopamine uptakin inhibitors ?, posted by zeugma on February 20, 2006, at 13:14:22
Bipolars and people with other mood disorders oftentimes have less dense prefronal cortexes.
There is a certain area of the subgenual prefronal cortex that shows some significant problems. Dr Manjii's work with lithium and valproate has shown that lithium and valproate can reverse this shrinkadge but that Antidepressants do not.
"I don't think any study has convincingly linked the broom (NE transporters) with either depression or ADHD, and yet the drugs that act on this mechanism are effective for both disorders."
Neither has any study convincingly linked SERT to depression!
Enhancing catecholamine activity may compensate for reduced prefronal cortex volumes and subsequent reduced regional blood flow. Or something like that :)
Linkadge
poster:linkadge
thread:611154
URL: http://www.dr-bob.org/babble/20060219/msgs/611441.html