Posted by zeugma on February 21, 2006, at 13:50:19
In reply to Re: this is interesting, posted by linkadge on February 20, 2006, at 16:13:04
> rTMS has been used with some sucess in individuals who are intollerant of medications used in ADD. >>
did you find that your attention/focus was improved while undergoing rTMS?
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> It has a number of unique biochemical effects, some of which are shared by ECT.>>then one would expect it to be especially good for the most severe depressions.
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> It illicits a strong responce in certain areas associated with the regulation of circadian rythem. >>my circadian rhythms are so disturbed that off medication, they are utter chaos.
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> It also shows an interesting pattern of receptor alteration. It desensitizes both 5-ht1a/b autoreceptors. It downregulates beta adrenoreceptors. I also think it has some effects on dopamine autoreceptors.>a while ago (maybe thirty years) there was a beta adrenoceptor hypothesis of AD action. there still is one, apparently, in panic disorder: the only AD's (so called) that are not also antipanic agents are trazodone, bupropion, and buspirone (buspirone is considered an AD by many investigators, and i agree) and none of these down regulate beta adrenoceptor receptors. so perhaps rTMS is an antipanic treatment as well?
(although I wonder if AP's are also antipanic agents, and clonazepam is a most powerful antipanic agent)
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> 15 hz also (surprisingly) led to an almost immediate reduction in my headaches.
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yes, that is surprising. given that the hypnagogic hallucinations/ sleep paralysis I experience with distressing frequency on Provigil feel like electrical shocks sometimes, and leave headaches and insomnia in their wake, I would be most reluctant to apply an electrical device to my skull. that is just my own prejudice.
> rTMS (like ECT) in animals, increases the behavioral sensitivity to stimulants.
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> (this may be due to 5-ht autorceptor downregulation, since mice 5-ht autoreceptor mutant mice also display an increased behavioral responce to stimulants)
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i've read that too. the dopamine/serotonin relationship is complex.
-z
> Linkadge
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poster:zeugma
thread:611154
URL: http://www.dr-bob.org/babble/20060219/msgs/611734.html