Posted by SLS on February 22, 2006, at 6:14:54
In reply to Re: NRIs are infact dopamine uptakin inhibitors ? » SLS, posted by zeugma on February 20, 2006, at 14:48:06
> Mazindol is also used in Europe to treat narcolepsy.
That's interesting. Despite it being such a high affinity DAT ligand that may or may not inhibit DA reuptake, it seems that the actions of mazindol result in large increases of NE. How might this fit into a model of narcolepsy?
> It is similar to nomifensine? (which was also looked at for ADHD).
> Did you find that nomifensine had a positive effect on cognition?
I was hoping that it would be. Unfortunately, mazindol might not be the potent DA reuptake inhibitor it was first thought to be. Nomifensine was indeed a DA reuptake inhibitor along with being a potent NE reuptake inhibitor. For some people with TRD, it was a powerful antidepressant with few side effects that has been the only thing that ever worked for them. I can't speak to its potential as an ADD drug. I never saw it used to treat it. However, it cleared-up my cognitive impairments for the time I responded to it. For me, an almost instantaneous improvement in cognitive function always accompanies a true antidepressant response.
> > What are your thoughts on sibutramine?
> Ken Gillman, who operates a site called http://psychotropical.com/, speaks highly of this as an AD, at least when I used to visit his site.Thanks for the link. I'll have to check it out.
> Have you ever tried it?
No, and I doubt I could get my prescription plan to pay for it. They require that you be weighed frequently and remain eligible for an indication of obesity.
> I wonder if D4 ligands have been looked at in depression.
I don't know. The only thing that comes to mind is sulpiride (but not amisulpride), which acts as a ligand to D4. It is an antagonist. Ropinirole seems to ring a bell also, but would be an agonist. If you come up with anything on ropinerole, please post what you find.
- Scott
poster:SLS
thread:611154
URL: http://www.dr-bob.org/babble/20060219/msgs/612000.html