Posted by zeugma on February 20, 2006, at 13:14:22
In reply to Re: NRIs are infact dopamine uptakin inhibitors ?, posted by SLS on February 20, 2006, at 12:48:41
> > I guess the bottom line is that NE uptake inhibitors help to regulate the "tone" of dopaminergic neurons by sweeping up their mess for them.
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> I said that wrong.
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> I meant to say that the NE uptake transporter pumps located on noradrenergic neurons act as brooms to sweep up the mess left by the release of dopamine from dopaminergic neurons; a mess for which the dopaminergic neurons are ill equiped to handle for themselves..>assuming all is well with the dopaminergic neurons, that is.
Presumably we mess around with NE uptake because there's a dysregulation in the system, but not necessarily with the broom that we toss out the window (inactivate). I don't think any study has convincingly linked the broom (NE transporters) with either depression or ADHD, and yet the drugs that act on this mechanism are effective for both disorders. Perhaps because the DA neurons in the prefrontal cortex are not sufficiently responsive to the pool of dopamine that is floating around (tonic DA), and hence require a less efficient cleaning system in order to compensate.
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> Steven Stahl, MD, has a good handle on this stuff.>>where did he buy his broom? my hands are splintered from all this :-)
-z
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poster:zeugma
thread:611154
URL: http://www.dr-bob.org/babble/20060219/msgs/611423.html