Posted by SLS on February 19, 2006, at 23:30:21
In reply to Re: NRIs are infact dopamine uptakin inhibitors ?, posted by zeugma on February 19, 2006, at 20:09:38
> The NE transporter has a higher affinity than the dopamine transporter for DA.
>
> This is why drugs like atomoxetine and desipramine are effective for ADHD symptoms.
>
> -z
It has been a long time since I looked at the literature on this subject, but we are not talking about synaptic dopamine here. It is the dopamine that "leaks" into the interstitial fluids that bathe the soma and axons that are taken up by the NAT. Yes, dopamine does play a role in the regulation (perhaps neuromodulation is a better word) of tone of NE neurons in the frontal cortex. Here, dopamine is acting in slow motion compared to the rapid transduction of signals within the synapse. NRIs are thus not really DA reuptake inhibitors at the synapse of NE or DA neurons.
- Scott
poster:SLS
thread:611154
URL: http://www.dr-bob.org/babble/20060219/msgs/611270.html