Posted by chemist on August 23, 2004, at 7:01:38
In reply to Re: P450-CYP2D6 » chemist, posted by Sad Panda on August 23, 2004, at 6:53:53
hello panda, the quick answer is: very much closer to that of venlafaxine in terms of comparable inhibition of 2D6. let me dig for a number, as i do have at my fingertips only the qualitative stats (fluoxetine is indeed noted at a strong inhibitor, venlafaxine and fluvoxamine come up the same for 2D6 inhibition, qualitatively). more soon, chemist
> > hi panda.....as for luvox, increased serum levels of DXM are reported in the prescribing information, but fluvoxamine is a weak inhibitor of 2D6: it is a potent substrate, however, of 2D6 and 1A2, and a potent inhibitor of 1A2. i would suspect that serum levels of DXM and metabolites via the 2D6 route would not be significantly enhanced by fluvoxamine as they are by fluoxetine, although i have no personal experience with DXM and luvox (xanax, dexedrine, caffeine/theophylline/theobromine, ambien, and several 1,4-benzos are fine with luvox, in my experience, past and present).....cheers to you, chemist
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> Hi there chemist,
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> When you say fluvoxamine is only a weak inhibitor of 2D6, where would it fall between velafaxine at 1.2x & fluoxetine at 9.1x?
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> Cheers,
> Panda.
>
>
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poster:chemist
thread:363939
URL: http://www.dr-bob.org/babble/20040821/msgs/381165.html