Posted by SLS on July 8, 2004, at 8:23:29
In reply to P450-CYP2D6, posted by Sad Panda on July 8, 2004, at 4:33:37
> Hi All,
>
> I am switching to Effexor + Nortriptyline & am wondering what my plasma levels of each drug will do since they both use the same enzyme. Should I reduce my Effexor doseage by 50%?
Hi Panda.Is this for moderate - severe major depression?
I wouldn't worry about the interaction. You would be doing yourself a disservice by reducing the dosage of either drug by 50%. Just treat the drugs as you would normally. I was on this combination for over 6 months. I responed only minimally, unfortunately.
I would decide upon a target dosage of Effexor and then use 75mg as your initial target for nortriptyline. Get a blood level after two weeks and go from there.
Effexor 300mg + nortriptyline 75-100mg
That should make for a good maximum. That's what I took. Opt for blood levels of nortriptyline closer to 150 mcg/mL
- Scott
poster:SLS
thread:363939
URL: http://www.dr-bob.org/babble/20040704/msgs/363972.html