Posted by zeugma on July 8, 2004, at 7:09:36
In reply to P450-CYP2D6, posted by Sad Panda on July 8, 2004, at 4:33:37
> Hi All,
>
> I am switching to Effexor + Nortriptyline & am wondering what my plasma levels of each drug will do since they both use the same enzyme. Should I reduce my Effexor doseage by 50%?
>
> Any & All help appreciated. :)Hi Panda,
Effexor is not a strong inhibitor of 2D6 but you will definitely want to titrate slowly on the nortriptyline. Unlike Effexor, it blocks NE reuptake at low dosages, so you may find benefit in lowering the Effexor dosage. Effexor and nortriptyline are pharmacologically more similar than Effexor and Rem. I think nortriptyline will raise Effexor levels more than the reverse, which should not be a problem since Effexor poses few toxicity problems. Good luck,
z
> Panda.
>
poster:zeugma
thread:363939
URL: http://www.dr-bob.org/babble/20040704/msgs/363949.html