Posted by zeugma on July 8, 2004, at 15:58:21
In reply to Re: P450-CYP2D6, posted by Sad Panda on July 8, 2004, at 10:20:10
I was taking 225mg Effexor + 30mg Remeron. Tonight I took 150mg Effexor, 15mg Remeron & 25mg of Nortriptyline. I will do this for a few days & then drop Remeron & increase Nort to 50mg. So far Nort is 'alerting', I hope it lets me sleep.
>
YMMV, but i found 25 mg nortriptyline to have no sedative effect. At 50 mg there was one, but due to nortriptyline's slow absorption (peak plasma levels reached 7-8.5 hours after administration) i took it 8 hours before I wanted to go to sleep. At 75 mg i would take it about 6 hours before sleep, and the drowsiness would come on slowly. at 100 mg there is less of a 'drowsy' effect; i just fall asleep about 3-4 hours after i take it.
poster:zeugma
thread:363939
URL: http://www.dr-bob.org/babble/20040704/msgs/364121.html