Posted by Larry Hoover on May 27, 2003, at 8:35:57
In reply to Re: Mg for Anxiety? L. Hoover, posted by JackT on May 27, 2003, at 7:21:01
> Larry,
>
> Thanks for your informative post.I knew I'd seen some nice descriptions of magnesium deficiency symptoms somewhere, and here they are. What is weird about magnesium deficiency is that the variety of symptoms in an individual can be very different from those in another. When mag deficiency is suspected, the real test is called magnesium loading, which is just another way of saying "give them magnesium and see if the symptoms disappear". Recommendations are 5 mg Mg/kg body weight (which is where I got the 350 mg recommendation for the "standard" body weight of 70 kg = 154 lbs.).
From:
http://www.mgwater.com/dur33.shtml"The symptoms of nervous primary chronic MD(magnesium deficiency) in the adult include non specific central peripheral and autonomic manifestations of neuromuscular hyperexcitability 1-8, 21-38.
Central or rather psychiatric symptoms consist of anxiety, hyperemotionality, fatigue, headaches (and sometimes migraine), insomnia, light-headedness, dizziness, nervous fits (panic attack particularly), lipothymiae, sensation of a 'lump in the throat', of 'nuchalgia' and 'blocked breathing'. Personality disorders are of neurotic type.
Neuromuscular disturbances symptoms are acroparaesthesiae, cramps, muscle fasciculations and myalgiae occurring more frequently than tetanoid or tetanic attack.
Autonomic functional complaints include chest pain, sine materia dyspnoea, blocked respiration, asthma-like dyspnoea, hepatobiliary dyskinesia, gastrointestinal spasms, precordialgia, palpitations, extrasystoles, dysrhythmias, Raynaud's syndrome, trends to orthostatic hypotension or conversely to borderline hypertension. In fact, the dysautonomic disturbances involve both the sympathetic and the parasympathetic systems: neurovegetative disorders may be amphotonic, alpha or beta sympathicotonic, vagotonic, with reactive hypoglycemia, pseudo allergic through hyper- receptivity to histamine and/or acetylcholine, sometimes with genuine allergy (Type I mainly). "
Most of the research into mag supplementation has been done in Europe. Go figure. This article measured anxiety parameters as a function of mag supplementation in the treatment of mitral valve prolapse.
Am J Cardiol 1997 Mar 15;79(6):768-72
Comment in:
Am J Cardiol. 1997 Oct 1;80(7):976.
Clinical symptoms of mitral valve prolapse are related to hypomagnesemia and attenuated by magnesium supplementation.Lichodziejewska B, Klos J, Rezler J, Grudzka K, Dluzniewska M, Budaj A, Ceremuzynski L.
Department of Cardiology, Postgraduate Medical School, Grochowski Hospital, Warsaw, Poland.
Mitral valve prolapse syndrome (MVP) is a frequent disorder characterized by a number of complaints which lessen the quality of life. The pathogenesis of MVP symptoms has not been fully elucidated. Hyperadrenergic activity and magnesium deficiency have been suggested. This study was designed to verify the concept that heavily symptomatic MVP is accompanied by hypomagnesemia and to elucidate whether magnesium supplementation alleviates the symptoms and influences adrenergic activity. We assessed serum magnesium in 141 subjects with heavily symptomatic primary MVP and in 40 healthy controls. Decreased serum magnesium was found in 60% of patients and in 5% of controls (p <0.0001). Patients with low serum magnesium were subjected to magnesium or placebo supplementation in a double-blind, crossover fashion. Typical symptoms of MVP (n = 13), intensity of anxiety, and daily excretion of catecholamines were determined. After 5 weeks, the mean number of symptoms per patient decreased from 10.4 +/- 2.1 to 5.6 +/- 2.5 (p <0.0001), and a significant reduction in weakness, chest pain, dyspnea, palpitations, and anxiety was observed. Increased noradrenaline excretion before and after magnesium was seen in 63% and 17% of patients, respectively (p <0.01). Mean daily excretion of noradrenaline and adrenaline was significantly diminished after magnesium. It is concluded that many patients with heavily symptomatic MVP have low serum magnesium, and supplementation of this ion leads to improvement in most symptoms along with a decrease in catecholamine excretion.
Lar
poster:Larry Hoover
thread:229017
URL: http://www.dr-bob.org/babble/20030525/msgs/229392.html