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Re: abilify/trileptal/zoloft » cybercafe

Posted by Ritch on May 22, 2003, at 22:07:34

In reply to Re: abilify/trileptal/zoloft, posted by cybercafe on May 22, 2003, at 16:27:59

> Ritch, I'd like to say thanks for bringing up the bp issue with effexor xr. i managed to get mine checked, found out it was high, and get off the stuff. which is great, because the tremors were really inhibiting my social life. now i can go out and start meeting some cute girls :)

Geez, the tremors must have been fairly brutal! :)

No withdrawal effects or rebound anxiety from the Effexor? How is your sleep (improved/worsened)?


> However! it (Zyprexa) does block dopamine receptors in my limbic system, and that is bad for my ADD and that is where aripiprazole seems like a unique solution.
> ummm... i think dopamine also has to do with drowsiness.. and since it's a partial agonist rather than an antagonist, that must help as well

That's what my pdoc crowed about (the "partial agonist" activity of Abilify at the D2 receptor), however, if you read the insert carefully you will see high *affinity* for the D2 receptor-that says antagonist all over the place to me-semantics(?). Otherwise how could this med cause considerable akathisia problems in some patients?


> >The only success I've found with long-half-life meds was "loading" Prozac and taking it two-three times weekly instead. It was still uneven to me and I didn't like that way of dosing.
>
>
> actually i don't think you'd need a loading dose... the long half life means you could just start taking 15 mg/day rather than starting with a lower dose and working your way up
>
> if one of the DRD2/5ht2 antagonists does not work for me aripiprazole will be my last hope

Oh, I see what you mean-you start off with a higher dose from the getgo....


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poster:Ritch thread:227600
URL: http://www.dr-bob.org/babble/20030520/msgs/228465.html