Posted by Ritch on May 21, 2003, at 22:12:47
In reply to Re: abilify/trileptal/zoloft, posted by cybercafe on May 21, 2003, at 18:59:23
> >one particular thing.. possibly over-sedated on the Abilify as well. It does have a long half-life. It may take a week or longer for the drug's level to reach a steady state. That's one thing I don't like about meds with lengthy half-lives like that--you don't see the response of a dose change for a long time-- and the longer the time goes by the easier it is to confuse with "typical" mood-cycling patterns.
>
> Abilify is sedating? darn
>
> i also was concerned about abilify's long half life ... but ... can't this be compensated for by a loading dose?
>
>
Cyber, I haven't tried the stuff. My pdoc told me it doesn't have the weight gain troubles that Zyprexa does. It has "moderate" affinity for the serotonin transporter-which makes it an SRI in some ways-and that usually means insomnia or agitation for some people. It isn't *supposed* to be near as sedative as Zyprexa or Seroqel. I have got a sample package to try, but I ain't going there. To me, from reading the insert in the sample package it looks like about three or four drugs in one. It looks like an SRI+Buspar+Risperdal all bundled into one. The lessened drowsiness is probably its lower antihistaminic properties. My pdoc also mentioned that asthenia with it is much reduced (muscle weakness-listlessness) because of reduced NE agonist(?) activity compared with the others. The only success I've found with long-half-life meds was "loading" Prozac and taking it two-three times weekly instead. It was still uneven to me and I didn't like that way of dosing.
poster:Ritch
thread:227600
URL: http://www.dr-bob.org/babble/20030520/msgs/228240.html