Posted by fachad on June 12, 2002, at 23:07:53
In reply to Re: Trimip= cholenergic rebound, EPS, etc (long expl.) » fachad, posted by Chloe on June 12, 2002, at 9:42:41
Chloe,
I think the information about receptor affinities is very interesting and it does provide some basis of comparison between different TCAs.
However, as my pdoc put it, this data is derived from rat brain tissue that had been blenderized, centrifuged, and then put into a test tube.
How closely that data is going to predict the way the meds are going to act a living human body is very difficult to predict.
Hence the origin of the PSB saying, "Your Mileage May Vary" (YMMV).
> >> fachad: I've seen other people become short fused on ami. I don't know if anyone has tried to tie it to NE reuptake or anything else.
>
>
> Fachad,
> This info is so invaluable. It is so wonderful to correspond with you. You have helped so much. Google, medline, etc search hasn't been as helpful as you have been to me. I am so appreciative!
>
> That is interesting you have heard of others getting short fused on Ami. Do you think this is simply related to Ami? Have you heard of Doxepin causing grouchiness too??? I wonder if all the ACh properties have something to do with this the grouchiness. Can you speculate?
>
>
> >> As far as the NE potency, here are a few numbers:
> >
> > Drug-------NE reuptake
> >
> > ami----------4-------
> > nortrip-----25-------
> > imimp--------8-------
> > desip------110-------
> > trimp------0.2-------
> > dox----------5-------
> >
>
> Your charts are so helpful! I love the science part of meds.
> Well, if it is the NE reuptake, Doxepin has slightly more! So I guess it wouldn't make a difference...But I am just really wanting to find out if I could be more civil on another TCA.
>
> BTW, Trimipramine really is out, because even though I have been back on the Ami for 3 days, I still have awful EPS. This happens when I take an AP. It takes weeks to stop the EPS that only a pill or two with dopamine can cause :(.
>
>
> >>fachad: I don't mind at all - I like to be able to share some of this stuff I've picked up. Another cool thing about doxepin, it comes in a liquid form. I just like that idea both on general principal, and because it allows for very minute dosage adjustments. Doxepin is also a dirt cheap generic.
>
> Thanks again for sharing your insights and experiences. Look forward to hearing more, if you have the energy!
>
> >> Hope doxepin works for you.
> Me too! But I am kinda scared to try...Med changes are always such an adjustment! And a gamble.
> Chloe
poster:fachad
thread:108844
URL: http://www.dr-bob.org/babble/20020609/msgs/109651.html