Posted by Elizabeth on November 10, 2001, at 22:38:02
In reply to Re: DXO vs. DXM (sidetrack) » Elizabeth, posted by Cam W. on November 9, 2001, at 22:30:49
Thanks! Links to articles are always welcome -- I consider my education to be a lifelong process (plus I just like reading about this stuff). I think they didn't use enough codeine -- it's pretty weak. Do other opioids help with cough, as a rule?
> It sounds like you unfortunately took a "fun" dose of DM.
(I wouldn't call it fun so much as weird. I guess it was kind of interesting.)
I took 30 mg -- the recommended dose for cough, equivalent to either 5 or 10 mL of Robitussin Max, I think. There's some indication that I'm deficient of CYP 2D6 (my desipramine levels were way high when I had them checked and rechecked); desipramine also probably competitively inhibits that enzyme, if nothing else. (Bupe is metabolized via 3A4, I think, and it doesn't affect NMDA receptors so far as I'm aware so there shouldn't have been additive effects.)
> Fisherman's Friend really has no "active" ingredients, just a little eucalyptus and menthol; but it works!
Ahh! I do have some "unmedicated" nose spray that sort of helps a little. I'll see if I can dig it up.
> Opiods that block the receptors in the cough center of the brainstem would probably work better than BUPH (ie. the lack of cougn control activity may have something to do with the agonist activity).
Buprenorphine definitely doesn't work for cough. How do I tell if a particular drug will help? Bupe is supposedly a partial mu agonist and a kappa antagonist (FWIW).
> I'm not sure that you wouldn't get a antitussive effect with codeine (aside from the low doses talked about in the above article) or hydrocodone.
Codeine doesn't work very well for me (this could also be explained by enzyme deficiency), but I'll give hydro a try. Gosh, I wonder if it would work -- does the antitussive effect have anything to do with opioid receptors? Because bupe blocks the effect of other opioids -- it clings tight to the mu receptor.
> You could try lowering the DM dose to about a quater to a half and see if that works.
The pills are hard to slip, but tonight I tried taking 1/4 pill. I seem okay so far, but it hasn't been long.
> The quote was from "I Am The Walrus" by the Beatles.
Ahh. Not my generation (although I do like a lot of Beatles songs -- "Happiness is a Warm Gun" is probably my favorite, of the ones I know).
> It is about taking acid and going to a concert, where the anticipation of the band coming and sensory overrload of the crowd would make one feel even more detached from reality, than one would ordinarily be from taking acid. Hence, "sitting on a cornflake, waiting for the band to come" is imagery from this experience. I have also heard it explained as "walking on bubbles or bubble wrap".
Well, I don't think this was a hallucinogenic trip. I mean, I wasn't seeing colors or anything.
> Good luck peeing that bug out, Sweetie. - Cam
Thanks!
-elizabeth
poster:Elizabeth
thread:83228
URL: http://www.dr-bob.org/babble/20011104/msgs/83845.html