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Re: dextrophan vs. dextromethorphan CAM

Posted by JohnX2 on November 5, 2001, at 16:23:58

In reply to Re: dextrophan vs. dextromethorphan CAM, posted by JGalt on November 5, 2001, at 15:54:50


Supposedly the dextrorphan doesn't readily
cross the blood-brain barrier (but how much so)
and the dxm quickly converts to dextrorphan
rather quickly. Hence motivation to inhibit
the conversion.

thnkx,
john


> Hey John...Well the article itself states that those with lower affinities are almost always safer, so I would say that, yes, it would be safer with a higher ratio DXM:DXO
>
> Of course the article itself states that drugs with lower receptor affinities are less toxic in general, so it seems likely that that is true. Also, I headed on over to the dxm faq and did some reading up on the conversion process DXM > > DXO and they state that it is primarily done by the CYP 2D6. They suggest that this conversion can be reduced by a number of things, including:
> taking Dextromethorphan polistirex instead of DXM HBr
> injecting DXM instead of using it orally
> taking it with a CYP2D6 inhibitors.
>
> To look over everything they said, go here:
> http://www.lycaeum.org/drugs.old/synthetics/dxm/faq/general_info.html and scroll down to 4.3 for the stuff I was talking about.
>
> To look at a small list of CYP2D6 inhibitors, go to:
> http://www.lycaeum.org/drugs.old/synthetics/dxm/faq/appendices.html#toc.15.1
>
> (there's quite a lot of them, including prozac and antihistamines)
>
> They also back up that DXO binds more to the NMDA receptor than DXM (which they say binds more to the PCP2 and sigma receptors).


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poster:JohnX2 thread:83228
URL: http://www.dr-bob.org/babble/20011104/msgs/83282.html