Posted by JGalt on November 5, 2001, at 15:54:50
In reply to Re: dextrophan vs. dextromethorphan CAM, posted by JohnX2 on November 4, 2001, at 23:41:51
Hey John...Well the article itself states that those with lower affinities are almost always safer, so I would say that, yes, it would be safer with a higher ratio DXM:DXO
Of course the article itself states that drugs with lower receptor affinities are less toxic in general, so it seems likely that that is true. Also, I headed on over to the dxm faq and did some reading up on the conversion process DXM > > DXO and they state that it is primarily done by the CYP 2D6. They suggest that this conversion can be reduced by a number of things, including:
taking Dextromethorphan polistirex instead of DXM HBr
injecting DXM instead of using it orally
taking it with a CYP2D6 inhibitors.To look over everything they said, go here:
http://www.lycaeum.org/drugs.old/synthetics/dxm/faq/general_info.html and scroll down to 4.3 for the stuff I was talking about.To look at a small list of CYP2D6 inhibitors, go to:
http://www.lycaeum.org/drugs.old/synthetics/dxm/faq/appendices.html#toc.15.1(there's quite a lot of them, including prozac and antihistamines)
They also back up that DXO binds more to the NMDA receptor than DXM (which they say binds more to the PCP2 and sigma receptors).
poster:JGalt
thread:83228
URL: http://www.dr-bob.org/babble/20011104/msgs/83278.html