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Re: MAOI vs SSRI linkadge

Posted by SLS on December 5, 2022, at 11:55:25

In reply to MAOI vs SSRI, posted by linkadge on October 22, 2022, at 17:39:33

Hi, Ed.

> I don't think there are any head to head trials comparing the use of these two classes for first episode depression but...
> I wonder...
> If you took 1000 first time depressed patients and randomly prescribed either parnate or escitalopram, I wonder which med would produce a higher response / remission rate.

> MAOIs are currently reserved as a third line treatment, but I just wonder what the repsonse would be if they were given as a first line treatment.

MAOIs easily get more people well than any other single drug. This is the answer given by clinicians without hesitation who actually know how to work with the stuff. I think diet and medication restrictions reflect a higher risk profile than SSRIs. I think that this is the number one reason why doctors don't make MAOIs a first-line treatment. Efficacy is not questioned.

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.




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