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Re: MAOI vs SSRI undopaminergic

Posted by SLS on October 28, 2022, at 20:40:38

In reply to Re: MAOI vs SSRI SLS, posted by undopaminergic on October 28, 2022, at 11:41:12

> > >
> > > > What if you took an anti-manic along with the memantine?
> > > >
> > >
> > > That might be worth trying.
> > >
> > > -undopaminergic
> >
> >
> > If Zyprexa (olanzapine) has had any beneficial effect for depression when added,
> >
> I'm not entirely sure about this, but once olanzapine seemed to help my motivation briefly (as in one dose, possibly two). I've read that serotonin 5-HT2A antagonists can increase dopamine release in the prefrontal cortex, but I also seem to recall that this effect was not sustained with chronic dosing.
> > regardless of the amount of time that it provided benefit, this might be an indicator that adding the right atypical antipsychotic might act as a synergist to memantine in treating your depression and also prevent mania. Since weight-gain is often a side effect of Zyprexa, finding another AP might solve that problem. Saphris (asenapine) and Latuda (lurasidone) come to mind. I don't know enough about Fanapt (iloperidone), but I would search the Internet for information.
> >
> Well, I'm on clozapine, trimipramine, and sulpiride, so I don't need more antipsychotics. Alas, I'm not in a position to take memantine at this time.
> > The other anti-manic strategy is to use anticonvulsants. Trileptal (oxcarbazepine), Depakote (valproate), topiramate (Topamax) are worth looking into. They sometimes demonstrate antidepressant effects when used as an adjunct to antidepressants.
> >
> That is interesting. I take 200 mg/day of lamotrigine, but I'm inclined to think it has no effect.

I completely forgot about lamotrigine. It is a necessary component to my treatment response to depression. However, I don't know about its potential as an anti-manic agent. I don't do well with lamotrigine until I reach 300 mg/day. Most people do well with 200 mg/day, I think. Importantly, I do get a partial improvement at 200 mg/day. Lamotrigine is not an all-or-nothing response.

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.




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