![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 236 to 260 of 262. Go back in thread:
Posted by europerep on November 1, 2011, at 13:39:29
In reply to Re: opiates and major depression » europerep, posted by Chairman_MAO on October 31, 2011, at 20:59:05
> Which "side effects" (in pharmacology, there are only effect, "side effect" is a value judgement) would these be exactly? How am I supposed to prove a negative?
Well, how about "dysphoric mania leading to suicides"? You seem to feel quite strongly about that one. Can you point to any study that says that buprenorphine treatment in TRD bears no risk of dysphoric mania leading to suicide? No, because there are no such studies. Until such types of studies are done, buprenorphine has to be considered an experimental treatment to be administered with caution.
> http://peele.net/lib/moa3.html
> http://www.globalizationofaddiction.ca/
>
> Two internationally recognized authorities. Enjoy.Really? That are your sources? Seriously?
> No, really, in reality there is thing called the "constitution", and with decisions such as Roe v. Wade and the abolition of slavery, I own my body. I decide what goes in it. If I am not harming anyone, leave me alone. If I harm someone, then punish me.
Another alternative reality. I don't really know anyone, other than internet people, who think that the constitution enshrines the right to buy any drug you want to get.
I'll consider this discussion over though. If you believe to be denied a fundamental right, sue. Oh no wait, all those judges and justices out there are just paid by people who want to make you take SSRIs for the rest of your life.
Posted by CaptainAmerica1967 on November 2, 2011, at 11:28:30
In reply to Re: opiates and major depression » CaptainAmerica1967, posted by SLS on November 1, 2011, at 5:40:40
> Hi.
>
> > Best wishes in trying buprenorphine-Subutex if you plan to try it. 1995 Harvard Study by Bodkin and currently a clinicaltrials.org is studying the effects of bup in late life TRD (BUILD study?)
>
>
> Would you be able to post a link to the study?
>
> Thanks.
>
> I am hoping that I won't need buprenorphine, but I guess I should start working on my doctor now to try to get him to change his mind. He doesn't want to use it on me.
>
>
> - Scott
--------------------------------------------------There are actually two studies with buprenorphine going on; the current clinical trial on late life TRD (Build) and one that hasn't started yet (BUO-TRD) both in Pittsburg, PA
http://clinicaltrials.gov/ct2/show/NCT01071538
http://clinicaltrials.gov/ct2/show/NCT01407575I can no longer find the original Bodken 1995 Harvard Study using "liquid buprenorphine" which is 50% more bioavailable squirting under the tongue with the max dose in the study 2mg/d compared to sublingual tablet (Sutuex) with a max dose of eqivalent to 4mg/day.
I end up paying cash even with insurance for the Subutex or about $100 a month but if you're an addict, I think nearly 100% is covered which isn't right because many meds are used off label; Inderal (propanolol) for mirgraine, trazodone as a hypnotic or Tricyclic Antidepressant (Anti-Cholinergic effect) to prevent enuresis or bedwetting, but the last two are only classified as antidepressant.
I have osteoarthritis and the lowest dose of the new Buprenorphine patch (Butrans) is 5mcg/micrograms per hour or eqivalent to 5mg of Subutex-bupreneorphine, 1 more mg than I'd normally be taken but at least I wouldn't be forking out $100 of my own each month.
The Suboxone has the anti-addiction medication naloxone mixed with the buprenorphine at a 4:1 ratio (bup to nal) which may or may not help the addiction process (very doubleful as I worked as a clinical pharmaceutical consultant and I know the tricks pharmaceutical companies play once a medication goes generic and when Subutex went generic, they can out with Suboxone which isn't better than Subutex but several times more expensive, but I actually got my insurance to cover the Suboxone instead of the Subutex, but I know why; the cost of Suboxone was about 3-4x that of regular buprenorphine and Suboxone even more expensive with insurnace coverage so I opted to stay on Subutex but hope to get Burans patch which should be covered for me but my psychiatrist has been hesitant to go to it either thinking it's not as effective or the 1mg more of buprenorphine. I'm thinking more cash in my pocket and maybe even feeling better wtih 5mg of bup.
I got Buprenex (injectable liquid bup) covered as I have osteoarthritic pain and any physician can RX it without a triplicate, vial of buprenorphine for injection which mens you'd really become addicted, but like the Harvard study I would just squirt bup underneath my tongue or use intranasally (more bioavailable) but to get close to the dose of Harvard study of 2mg, I would have had to buy so many vials that it was 3-4x the cost of Subutex tablet equal 4mg of the tablet buprenorphine (Subutex) used sublingually with insurnace still and that's why I stay with the 2mg of Subutex twice a day which equals the max of the Harvard liquid bup. The only problems that all psychiatrist have is that the darn FDA will not recognize opioid as valid treatment for refractory depression, but believe just like herbal or integrative medicine that the view will change over the years.
Posted by JahL on November 2, 2011, at 14:10:48
In reply to Re: opiates and major depression » CaptainAmerica1967, posted by SLS on November 1, 2011, at 5:40:40
> I am hoping that I won't need buprenorphine, but I guess I should start working on my doctor now to try to get him to change his mind. He doesn't want to use it on me.
>
>
> - ScottHey Scott.
I haven't posted here in a few years so I'm a little vague on your current situation. Can I ask what your experiences of opiates are, if any? I ask because the description you give of your illness resonates with my own like no other I have read here - and I first started posting back in '99! Like yourself, I have trialled 60, maybe 70 'meds', with only sporadic and muted success. However, codeine excepted, every opiate I have ever tried has brought about a swift and tolerable improvement. My problem is that here in the UK the more potent opiates - which I believe might bring about something resembling full remission - are not available. Anyway, feel free to interrogate me if you think it could be of any help :)
Best wishes,
J
Posted by SLS on November 2, 2011, at 14:31:09
In reply to Re: opiates and major depression » SLS, posted by JahL on November 2, 2011, at 14:10:48
Hey JahL!
It has been a long time. When I saw your name, it brought a smile to my face and triggered a few distant memories.
I am just about out the door, so I'll write more later. I just wanted to say hi.
Be well.
- Scott
Posted by europerep on November 2, 2011, at 15:15:49
In reply to Re: opiates and major depression, posted by CaptainAmerica1967 on November 2, 2011, at 11:28:30
Thanks for posting that link, I wasn't aware of that new study to be done in Pittsburgh. I wish it were bigger in terms of patients participating, but a placebo-controlled study sure is a step in the right direction.
Again, thanks for that...
Posted by Chairman_MAO on November 3, 2011, at 19:38:25
In reply to Re: opiates and major depression » Chairman_MAO, posted by europerep on November 1, 2011, at 13:39:29
Then you obviously don't know very many people who have read the constitution or know about the history of prohibition.
Bruce Alexander and Stanton Peele are two very reputable sources.
http://en.wikipedia.org/wiki/Rat_Park
On what basis do you think alcohol prohibition was overturned? I mean, really, it's not my fault that you haven't met any people in real life that don't know about drug policy.
Posted by europerep on November 4, 2011, at 9:45:53
In reply to Re: opiates and major depression » europerep, posted by Chairman_MAO on November 3, 2011, at 19:38:25
So you accept those studies that say what you want them to say and dismiss all others?
The point is, we are starting from different premises. You want the doctors who stand between patients and narcotics to be gone - I want them to be better.
Anyhow, good luck with that "addiction isn't real" thing. (Yes, this is a straw man argument, but your argument is almost equally absurd.)
Posted by CaptainAmerica1967 on November 4, 2011, at 10:09:01
In reply to Re: opiates and major depression » CaptainAmerica1967, posted by europerep on November 2, 2011, at 15:15:49
> Thanks for posting that link, I wasn't aware of that new study to be done in Pittsburgh. I wish it were bigger in terms of patients participating, but a placebo-controlled study sure is a step in the right direction.
>
> Again, thanks for that...
----------------------------------You're welcome. I'd just like to see the pharmaceutical companies branch out on their R&D like buprenorphine or other mechanism of actions instead of just "tweaking current drug formulas as opposed to developing new classes of molecules". http://www.dana.org/media/detail.aspx?id=5392
Beyond those of us with resistant disorders, there are those 40% of patients that don't respond at all to anything even though they might not be as deeply depressed
Posted by Chairman_MAO on November 10, 2011, at 5:45:36
In reply to Re: opiates and major depression » Chairman_MAO, posted by europerep on November 4, 2011, at 9:45:53
> So you accept those studies that say what you want them to say and dismiss all others?
>
How many studies, exactly, do you want me to cite? Those were just two researchers. What studies are you citing? We're talking about something conceptual here; you have to start there first before one even begins to look at studies. What do you want me to demonstrate?> The point is, we are starting from different premises. You want the doctors who stand between patients and narcotics to be gone - I want them to be better.
>No, I don't want doctors to be gone. I want people to consult with doctors because they want to, not because they have to. That would have the effect of making doctors be better because they'd have to be in order to make money. You can be a professor of pharmacology at a medical school and know more than most doctors about drugs, and yet you need a permission slip to buy one. That doesn't make a bit of sense to me whatsoever, especially given that we're able to buy cigarettes and alcohol at the corner store.
> Anyhow, good luck with that "addiction isn't real" thing. (Yes, this is a straw man argument, but your argument is almost equally absurd.)
Posted by psychobot5000 on November 14, 2011, at 15:08:11
In reply to Re: opiates and major depression » europerep, posted by Chairman_MAO on November 10, 2011, at 5:45:36
Europerp: throughout this conversation I find your responses to the very helpful and knowledgeable Chairman_MAO to be rather haughty and ungentlemanly (or unladylike?). I don't see the need for any of it.
As for some questions earlier about buprenorphine's pharmacology, I don't think I saw them answered. I will attempt to do so. It's a partial agonist of mu-opioid receptors (meaning it only partway activates those receptors once it binds, so there's a lower 'ceiling' to its effect, no matter how many receptors it binds to), but has -very- -high- affinity for those receptors, so, yes, it attaches to them strongly and can displace some other medications. It's also, if I remember correctly, a kappa-opioid antagonist, but I'm skeptical about how important that is to its mood benefits.
I have been prescribed suboxone for TRD, and a quarter of a 2mg (so .5mg buprenorphine plus whatever nalaxone was in it) pill bowled me over. I'd recommend starting from .2mg and building from there.
Also, for that matter: there was confusion, above, about the second ingredient in suboxone is. It's nalaxone, the opiate antagonist used to prevent abuse by injection, not nalTREXone, the opiate antagonist used for various other things, including, I've heard, preventing tolerance.
Posted by SLS on November 15, 2011, at 6:52:28
In reply to Re: opiates and major depression » SLS, posted by JahL on November 2, 2011, at 14:10:48
> > I am hoping that I won't need buprenorphine, but I guess I should start working on my doctor now to try to get him to change his mind. He doesn't want to use it on me.
> I haven't posted here in a few years so I'm a little vague on your current situation. Can I ask what your experiences of opiates are, if any?
I have no experience with opiates.
> I ask because the description you give of your illness resonates with my own like no other I have read here - and I first started posting back in '99! Like yourself, I have trialled 60, maybe 70 'meds', with only sporadic and muted success.
I really don't know what keeps us going.
> However, codeine excepted, every opiate I have ever tried has brought about a swift and tolerable improvement.
Which opiate did you think was best?
Thanks, JahL
- Scott
Posted by Chairman_MAO on November 15, 2011, at 6:59:49
In reply to Re: opiates and major depression » JahL, posted by SLS on November 15, 2011, at 6:52:28
http://en.wikipedia.org/wiki/JDTic
Holds a lot of promise.
Posted by europerep on November 15, 2011, at 18:07:12
In reply to Re: buprenorph dosage and pharmacology, posted by psychobot5000 on November 14, 2011, at 15:08:11
> Europerp: throughout this conversation I find your responses to the very helpful and knowledgeable Chairman_MAO to be rather haughty and ungentlemanly (or unladylike?). I don't see the need for any of it.
>Well, if you want criticize me for being disrespectful, you might start by writing my name correctly maybe?
Besides that though, my point is simply that raging an internet war against psychiatrists who don't say "hey, take some tramadol" upon being told that a first trial of fluoxetine wasn't successful, is pointless. It's just not gonna solve anyone's problems.
Posted by Erif on December 21, 2011, at 16:10:47
In reply to Re: opiates and major depression » CaptainAmerica1967, posted by Chairman_MAO on October 19, 2011, at 14:09:38
Hi All (maybe this should be a new thread...sorry)
I'd like to direct this post particularily to Jeff as I've been reading a lot of his threads...I also have (and have had) treatment resistant major depression, and anxiety disorder, for Many years. Currently, I often can't get out of bed; my thoughts are very often torturedly painful and if I do get out of bed, when it's so bad, it doesn't help. I've tried about every anti-depressant (including MAOI's) there is as well as other psychotrophic medications. I've also tried cold shower therapy and exercise. Low dose Amphetimines can help a little (a few hours during a given day) but only if I don't take them more than a day or two in a row. When they don't work at all (basically every other day, at best, I'm even more nervous, depressed and my thoughts even more tortured...norepinephrine/dopamine increase then depletion I guess) Currently I'm trying (for the 2nd time) adding welbutrin to my amphetamine, dexadrine. I survive my time that dexadrine is not helping at all, with klonopin (which I hold to a dose as low as I can as my memory is getting less good than it was) and anti-histaimines (this can help, an hour or two, if I'm able to make myself sleepy without actually going to sleep)
I have a lot of tragedy as well as, unfortunately, abuse in my background. Complex Post Traumatic Stress Disorder plays a significant role in my depression. I've had therapy for Many years, but have almost Never been able to trust a therapist with my emotions... I try, but therapy was/is like intellectual reporting/discussing forEver (telling about horrible events with no emotion) which I've come to Hate after soooo many years. Much of my PTSD is around people problems so I have huge trust issues which makes it especially hard to heal w/ therapist/people; and the pain of grieving alone/depressed becomes so overwhelming to me that I can't seem to do that either.
Anyway, so Jeff I understand that your depression is biological and that you don't have abuse in your background. I know that you have had Monumental loss (I can personally relate to your feelings about that song by Bread and reading that touches my heart.) Have you been able to grieve the Major Losses in your life..... not just the sad, tragic loss of your sweet parents but also the loss of your life caused by depression..?.. In fact, the way we all suffer major grieving everyday is, at least, justified anyway. If you have been able to grieve, I'm glad. If not, I can relate; I've only been able to do a very little bit of grief in proportion to my Losses. My Lost Life. Currently, I'm trying taking a "Re-evaluation Counseling"/Co-counseling class which maybe possibly (I hope to God) might help with this (possibly because of the mutuality of the approach.) I recommend at least trying "Re-evaluation Counseling" for anyone with Complex Post Traumatic Stress Disorder (you might need to be able to overlook the occasional slightly cultish or even loopy vibe that can be associated w/ the "RC" culture) but I think the basic theory and rules of practice are good.
best,
E
PS I'm also thinking about trying ketamine and I really hope depression-treatment level maintanance doses wouldn't cause urinary system damage.
Posted by Erif on December 21, 2011, at 16:13:14
In reply to Re: opiates and major depression » CaptainAmerica1967, posted by Chairman_MAO on October 19, 2011, at 14:09:38
Hi All (maybe this should be a new thread...sorry)
I'd like to direct this post particularily to Jeff as I've been reading a lot of his threads...I also have (and have had) treatment resistant major depression, and anxiety disorder, for Many years. Currently, I often can't get out of bed; my thoughts are very often torturedly painful and if I do get out of bed, when it's so bad, it doesn't help. I've tried about every anti-depressant (including MAOI's) there is as well as other psychotrophic medications. I've also tried cold shower therapy and exercise. Low dose Amphetimines can help a little (a few hours during a given day) but only if I don't take them more than a day or two in a row. When they don't work at all (basically every other day, at best, I'm even more nervous, depressed and my thoughts even more tortured...norepinephrine/dopamine increase then depletion I guess) Currently I'm trying (for the 2nd time) adding welbutrin to my amphetamine, dexadrine. I survive my time that dexadrine is not helping at all, with klonopin (which I hold to a dose as low as I can as my memory is getting less good than it was) and anti-histaimines (this can help, an hour or two, if I'm able to make myself sleepy without actually going to sleep)
I have a lot of tragedy as well as, unfortunately, abuse in my background. Complex Post Traumatic Stress Disorder plays a significant role in my depression. I've had therapy for Many years, but have almost Never been able to trust a therapist with my emotions... I try, but therapy was/is like intellectual reporting/discussing forEver (telling about horrible events with no emotion) which I've come to Hate after soooo many years. Much of my PTSD is around people problems so I have huge trust issues which makes it especially hard to heal w/ therapist/people; and the pain of grieving alone/depressed becomes so overwhelming to me that I can't seem to do that either.
Anyway, so Jeff I understand that your depression is biological and that you don't have abuse in your background. I know that you have had Monumental loss (I can personally relate to your feelings about that song by Bread and reading that touches my heart.) Have you been able to grieve the Major Losses in your life..... not just the sad, tragic loss of your sweet parents but also the loss of your life caused by depression..?.. In fact, the way we all suffer major grieving everyday is, at least, justified anyway. If you have been able to grieve, I'm glad. If not, I can relate; I've only been able to do a very little bit of grief in proportion to my Losses. My Lost Life. Currently, I'm trying taking a "Re-evaluation Counseling"/Co-counseling class which maybe possibly (I hope to God) might help with this (possibly because of the mutuality of the approach.) I recommend at least trying "Re-evaluation Counseling" for anyone with Complex Post Traumatic Stress Disorder (you might need to be able to overlook the occasional slightly cultish or even loopy vibe that can be associated w/ the "RC" culture) but I think the basic theory and rules of practice are good.
best,
E
PS I'm also thinking about trying ketamine and I really hope depression-treatment level maintanance doses wouldn't cause urinary system damage.
Posted by CaptainAmerica1967 on December 22, 2011, at 2:56:03
In reply to grief and major depression, posted by Erif on December 21, 2011, at 16:13:14
I think there are an whole array as we already know of division and subdivision of major depresssive disorders (unipolar, atypical unipolar, bipolar I and II, major depression association with temporal lobe epilepsy, major depression mixed sleep disorders and to many more to list).
Psychosocial factors such as a loss or PTSD from loss of a witnessing a parent at an early age could come into play into developing a disorder.
Also, genetic can play a prominent role as we know.
The number of treatments are phenomenal from typical psychopharmacology (Ivan Goldberg, MD has complied a good list on his website; http://www.psycom.net/depression.central.drugnames.html. I've taken almost every single one.
Other biological treatments like the "Gold Standard" doesn't work for everyone as I had it right after high school in 1985 and into 1985 for a whopping 70 something treatments with no effect.
The only biological treatments that helped me went I wasn't be ridden was hard physical exericise to where I sweat well. Exercise is known to affect all the major mood bolstering neurotransmitters but in addition affect/effect the natural opiates and the receptors something that none of the currently available antidepressants do except the tricyclics but only for pain or the mu receptors not against dynorphins which make you feel sluggish worn down, the opposite, enkephalins and endorphins so my psychiatrist by exercise said he had others that only get a great repsonse from physical exercise and used buprenorphine with them and so he tried me on sublinginual buprenorphine and for the first time since I was 15y/o and two years ago went I tried buprenorphine(Subutex-no naloxone). I had forgotten how good life can really feel normal and functional all the time; interesting paper I read about the gout medication allopurinal is that it too has "anatagonist activity a the kappa opioid receptors but is very weak but so is buprenorphine and why so many other drug companies are working on "specific kappa receptors antagonists/blockers that would probably made one feel a lot better than just a partial kappp antongist(go to http://en.wikipedia.org/wiki/Kappa_Opioid_receptor(all that time I could have done even better in high school and college; maybe went on further, dated "a lot" as that was last on my mind and a guilty feeling let down my sports teammates a star football player, promising state championship wrestler as I had gone to wrestling champ down in Pennsylvania at Lock Haven after having a great sophomore year and explovsive sprinter and shot putter. We all have our guilt on what we might have been able to do if I hadn't be the the horrific, dreadful, life altering mood disoders of various types of depression.Other biological therapies, I guessing because I read the brain is way overactive compared to non depressed patienet (more blood flow/more glucose being used; I had to read a paragraph twice sometines to capture all of it) that the bioligical treatment sleep depreviation which was one of the only treatments for depression prior to pharmacotherapy and ECT. I also read studies by the National Institute of Mental Health that cold water therapy use two-three times a day is effectiive antidepressant calming the overactive brain afterward increasing levels of endorphins and norepinephine from the locus cereuleau brain structure deep in the brain also associate with panic attacks by releasing to much and the cold shower desensitizes the LC and ehanches enodorphin production.
As far a my "grief" in life, yes, I got over the loss of my parents and other relatives at an early age and over the bad feelings that this was a daily lifelong struggle I would have to survive as I would attack it the best way I knew and that is with physical exercise, meditation, medications and "HOPES" for the future like once neurosurgeons and neurologist get the Dee Brain Stimulation down to a "T" in having know exactly where to place the stimulant electrodes for specific types of depresion, but there is always a risk with survery.
Posted by sukarno on December 25, 2011, at 13:40:15
In reply to Re: grief and major depression, posted by CaptainAmerica1967 on December 22, 2011, at 2:56:03
A psychiatrist once told me that antidepressants aren't very effective in treating depression caused by grief.
All I know is that smoking cigarettes helps me but at the same time I realize this is not a rational long-term solution. It is the only thing that works (moderately) at this point.
Perhaps that means that my depression is caused by a problem in the dopamine system. However, I have experienced many traumatic life events in a short period of time, so that stress can trigger depression too and possibly cause "chemical imbalances" of its own.
Posted by SLS on December 31, 2011, at 6:36:33
In reply to grief and major depression, posted by Erif on December 21, 2011, at 16:10:47
Hi Erif.
Nice post.
Columbia Presbyterian has a great program for treating grief and PTSD.
http://www.columbia.edu/cu/ssw/spectrum/2010-spring/complicated-grief.html
- Scott> Hi All (maybe this should be a new thread...sorry)
> I'd like to direct this post particularily to Jeff as I've been reading a lot of his threads...
>
> I also have (and have had) treatment resistant major depression, and anxiety disorder, for Many years. Currently, I often can't get out of bed; my thoughts are very often torturedly painful and if I do get out of bed, when it's so bad, it doesn't help. I've tried about every anti-depressant (including MAOI's) there is as well as other psychotrophic medications. I've also tried cold shower therapy and exercise. Low dose Amphetimines can help a little (a few hours during a given day) but only if I don't take them more than a day or two in a row. When they don't work at all (basically every other day, at best, I'm even more nervous, depressed and my thoughts even more tortured...norepinephrine/dopamine increase then depletion I guess) Currently I'm trying (for the 2nd time) adding welbutrin to my amphetamine, dexadrine. I survive my time that dexadrine is not helping at all, with klonopin (which I hold to a dose as low as I can as my memory is getting less good than it was) and anti-histaimines (this can help, an hour or two, if I'm able to make myself sleepy without actually going to sleep)
>
> I have a lot of tragedy as well as, unfortunately, abuse in my background. Complex Post Traumatic Stress Disorder plays a significant role in my depression. I've had therapy for Many years, but have almost Never been able to trust a therapist with my emotions... I try, but therapy was/is like intellectual reporting/discussing forEver (telling about horrible events with no emotion) which I've come to Hate after soooo many years. Much of my PTSD is around people problems so I have huge trust issues which makes it especially hard to heal w/ therapist/people; and the pain of grieving alone/depressed becomes so overwhelming to me that I can't seem to do that either.
>
> Anyway, so Jeff I understand that your depression is biological and that you don't have abuse in your background. I know that you have had Monumental loss (I can personally relate to your feelings about that song by Bread and reading that touches my heart.) Have you been able to grieve the Major Losses in your life..... not just the sad, tragic loss of your sweet parents but also the loss of your life caused by depression..?.. In fact, the way we all suffer major grieving everyday is, at least, justified anyway. If you have been able to grieve, I'm glad. If not, I can relate; I've only been able to do a very little bit of grief in proportion to my Losses. My Lost Life. Currently, I'm trying taking a "Re-evaluation Counseling"/Co-counseling class which maybe possibly (I hope to God) might help with this (possibly because of the mutuality of the approach.) I recommend at least trying "Re-evaluation Counseling" for anyone with Complex Post Traumatic Stress Disorder (you might need to be able to overlook the occasional slightly cultish or even loopy vibe that can be associated w/ the "RC" culture) but I think the basic theory and rules of practice are good.
> best,
> E
> PS I'm also thinking about trying ketamine and I really hope depression-treatment level maintanance doses wouldn't cause urinary system damage.
>
>
>
>
Posted by SLS on December 31, 2011, at 6:44:24
In reply to Re: grief and major depression, posted by CaptainAmerica1967 on December 22, 2011, at 2:56:03
Wow. You are one smart dude!
Do opioid kappa receptors recognize dynorphins?
- Scott
> I think there are an whole array as we already know of division and subdivision of major depresssive disorders (unipolar, atypical unipolar, bipolar I and II, major depression association with temporal lobe epilepsy, major depression mixed sleep disorders and to many more to list).
>
> Psychosocial factors such as a loss or PTSD from loss of a witnessing a parent at an early age could come into play into developing a disorder.
>
> Also, genetic can play a prominent role as we know.
>
> The number of treatments are phenomenal from typical psychopharmacology (Ivan Goldberg, MD has complied a good list on his website; http://www.psycom.net/depression.central.drugnames.html. I've taken almost every single one.
>
> Other biological treatments like the "Gold Standard" doesn't work for everyone as I had it right after high school in 1985 and into 1985 for a whopping 70 something treatments with no effect.
> The only biological treatments that helped me went I wasn't be ridden was hard physical exericise to where I sweat well. Exercise is known to affect all the major mood bolstering neurotransmitters but in addition affect/effect the natural opiates and the receptors something that none of the currently available antidepressants do except the tricyclics but only for pain or the mu receptors not against dynorphins which make you feel sluggish worn down, the opposite, enkephalins and endorphins so my psychiatrist by exercise said he had others that only get a great repsonse from physical exercise and used buprenorphine with them and so he tried me on sublinginual buprenorphine and for the first time since I was 15y/o and two years ago went I tried buprenorphine(Subutex-no naloxone). I had forgotten how good life can really feel normal and functional all the time; interesting paper I read about the gout medication allopurinal is that it too has "anatagonist activity a the kappa opioid receptors but is very weak but so is buprenorphine and why so many other drug companies are working on "specific kappa receptors antagonists/blockers that would probably made one feel a lot better than just a partial kappp antongist(go to http://en.wikipedia.org/wiki/Kappa_Opioid_receptor(all that time I could have done even better in high school and college; maybe went on further, dated "a lot" as that was last on my mind and a guilty feeling let down my sports teammates a star football player, promising state championship wrestler as I had gone to wrestling champ down in Pennsylvania at Lock Haven after having a great sophomore year and explovsive sprinter and shot putter. We all have our guilt on what we might have been able to do if I hadn't be the the horrific, dreadful, life altering mood disoders of various types of depression.
>
> Other biological therapies, I guessing because I read the brain is way overactive compared to non depressed patienet (more blood flow/more glucose being used; I had to read a paragraph twice sometines to capture all of it) that the bioligical treatment sleep depreviation which was one of the only treatments for depression prior to pharmacotherapy and ECT. I also read studies by the National Institute of Mental Health that cold water therapy use two-three times a day is effectiive antidepressant calming the overactive brain afterward increasing levels of endorphins and norepinephine from the locus cereuleau brain structure deep in the brain also associate with panic attacks by releasing to much and the cold shower desensitizes the LC and ehanches enodorphin production.
>
> As far a my "grief" in life, yes, I got over the loss of my parents and other relatives at an early age and over the bad feelings that this was a daily lifelong struggle I would have to survive as I would attack it the best way I knew and that is with physical exercise, meditation, medications and "HOPES" for the future like once neurosurgeons and neurologist get the Dee Brain Stimulation down to a "T" in having know exactly where to place the stimulant electrodes for specific types of depresion, but there is always a risk with survery.
>
>
Posted by alchemy on January 2, 2012, at 16:59:19
In reply to Re: grief and major depression » CaptainAmerica1967, posted by SLS on December 31, 2011, at 6:44:24
Someone had given me a sample & I took 2mg this morning. I have ended up dizzy, throwing up couple of times, and mostly sedated. I don't know if it has helped my mood or not, probably because of everything else.
Dang it!
Posted by larryhoover on January 2, 2012, at 23:02:30
In reply to just tried suboxone, posted by alchemy on January 2, 2012, at 16:59:19
2 mg is a pretty large "starter" dose, IMHO. I take one tenth of that, and I still get some drugged feeling. I take the version without naloxone in it, though.
I'm not sure, but I think it's having a positive effect on my mood and energy.
Lar
Posted by CaptainAmerica1967 on January 3, 2012, at 10:18:07
In reply to Re: opiates and major depression, posted by CaptainAmerica1967 on November 4, 2011, at 10:09:01
For those who missed all my Akermes pharmaceutical studyies on Buprenorphine plus some blocker so one will not get addicted to bup, here it is again.
I haven't been even looking for the clinicl trial on clinical trials dot gov for ALKS 5461 (buprenorphine plus ALKS 33) but I looked again at Alermes website, and it's just finished phase 1 (no press release) but can only find information for 1/2 of phase 1
Pipeline for Alkermes Company:
http://www.alkermes.com/Research-and-Development/Pipeline, and it say to go clinical trials dot com.
"ALKS 5461" is the combination buprenorphine plus that of ALKS 33 and buprenorphine. ALKS 33 has already finished phase II and going to phase 3. ALKS 33 is going to be indicated for alcohol addiction but didn't pass for binge eating.
http://www.drugs.com/clinical_trials/alkermes-announces-results-phase-2-study-alks-33-binge-eating-disorder-12083.htmlJust looked at clinical trials for company Alkermes (ALKS). Not sure if any conclusions yet except that the key will be the ALKS 33 study as I already know buprenoprhine works for me (hope it works for the study) and from what I can see on this study, they exclude anyone allergic to naltrexone making me think it's low dose naltrexone which is already used by psychiatrist given at night to increase natural levels of endorphins because the receptor overcome the small dose therefore increasing endorphins. Low Dose Naltrexone is used off lable for many autoimmune diseases like Huntington's, MS, etc which good success.
Here's all Alkerme's studies on clinical trial:
http://clinicaltrials.gov/ct2/results?term=ALKS
I've heard on the news recently and TV an advertisements for opioid inducted constipation.
Posted by CaptainAmerica1967 on January 5, 2012, at 9:25:45
In reply to Re: grief and major depression » CaptainAmerica1967, posted by SLS on December 31, 2011, at 6:44:24
Sorry, I missed this one Scott. I'm not sure what you mean by this question but I know that dynorphins work through Kappa receptors by Kappa binding dynorphins. One of the first symptoms I experienced at the age of 16 with anxiety, depression was a decreased libido and that might mean low dopamine as dopamine is the libido enhancing neurotransmitter besides PEA (phenylethylamine, short acting like in chocholate or long lasting increase of PEA by taking deprenyl-selegiline; also enhances brain longevity by increasing SOD, one of the bodies main antioxidants-rats lived almost twice as long on selegiline. I took selegiline while in college and couldn't foucs on studying as my libido was through the roof and would always be staring at various ladies in class instead of listening to the professor). Anyways, dynorphins decrease libido somehow via Kappa receptors binding. Oxytocin which is being studied as an antidepressant and is the cuddle love hormone (when in love) is associated somehow with dynorphins decreasing oxytocin via A negative feedback loop. Most of my life I took Nardil (I'm quite sure I lack GABA production produced in the nucleaus accumbens which also is the focus of deep brain stimulation and the area around Broadmanns 25-Helen Mayberg, MD, for depression, again an overactive brain) and MAOIs in general via the liver decrease testosterone production which further can cause depression and decreased libido (I think Nardil increases prolactin as well which inhibit libido) except until several year ago when I switched to Parnate which also decreases testosterone but the increase in dopamine from prevention of being broken down may counteract the liver decrease in testosterone. By the way, Buprenorphine and all opioids (heroin) decrease testosterone as well as lithium, haldol, marijuana, and barbiturates. My total tesstosterone (249-836) is very low normal being 252 (I'm 5' 11", 240 pounds, very low fat so little chance of conversion to estrogen and I lift weights and take 1000 IU of vitamin D which both are suppose to increase testosterone but mine is still low. It's really the "free testosterone" that has the benefits on the body; decrease c-reactive protein, cardiovascular disease, decrease in strokes, as well as decrease in osteoporosis, bone fracture, type 2 diabetes, metabolic disorder, sleep apnea, libido and other things like mood but most physicians including mine aren't very savvy when doing blood screening tests. OK, sorry, I got off the subject of dynorphins. So maybe Kappa antagonists block dynorphins as well to produce the antidepressant and antianxiety effect. I can say without a doubt that buprenorphine is a much better antianxiety medication than any type of benzodiazepine I've tried but maybe my anxiety is a subtype as describe in some literature on kappa antagonist. Lastly, I also first noticed feeling extremely warm and hot all the time like hot flashes but my thyroid tests were normal and I just looked this up and saw some correlation with body temperature and dynorphins.
Posted by CaptainAmerica1967 on January 5, 2012, at 10:29:12
In reply to Re: grief and major depression, posted by sukarno on December 25, 2011, at 13:40:15
I've went over my family history for depression which is low on both sides, but anxiety is very high and never knew my Dad's side as my Dad's Dad died went he was 8 years old so we never got to know that side of the family as they lived in Spring Lake, NJ and we lived in Upstate, NY but know alcolholism was (is) big on both sides of the families and maybe they tried to self medicate.
Stress at a young age might produce high cortisol levels preventing normal growth or full growth of the brain and I was told I cried constantly for no reason as a baby even prior to my Dad's death at age 5.
There's a very intersting theory about mood disorder for some individuals that the neurologist, professor, I had went to see after the accident. He had saw too many cases to count of infants that were handled rougly at birth with forceps which caused brain damage of the limbic system (mood)as the fontanelle are soft and many parents didn't recognize it at the time of delivery. Some GYNs used excessive force with the forcep on the temperol lobes at birth. I weighed almost 12 pounds (pure muscle like my Dad-six pack abs at birth) when I was delivered but don't know why they didn't do a C-section on my Mother but maybe they just didn't do many back then as it took the GYN twice as long to extract me. My Mother almost delivered me in the elevating going up to the labor and delivery floor of the hospital. The gyn put so much pressure on my temporal lobes (limbic system deep beneath-mood) that my temples drew blood and had forcep marks on my temples and I still have one on my right temporal lobe.
Physician do make mistakes (there human) and possible this GYN did and definitely the psychiatrist that gave me my 70 ECT's as he later put me on 1000 mg of trazadone which is a very high dose because of my refractory case. My Mother twice saw me go into a blink and stare motion with my eyes. She called the psychiatrist and wondered if it was a seizure and the psychiatrist said Desyrel wasn't known to cause seizures in the studies as it was a 5HT2C antagonist and said I probably had a panic attack and fainted. Boy, this psychiatrist was way off because he never had me checked out and said it was OK to drive and the following week I had a seizure while driving with my Mother in the passenger seat that killed my Mother. I was sent to a neurologist who did an EEG and diagnosed initially as petite mal seizure, but went off the desyrel and I had a completely normal EEG and the neurologist said the super high dose of desyrel mimicked a seizure disorder and I never had one. This neurologist/professor also told me about the theory of seeing many infant handled too roughly at birth with forceps and later developing mood disorders and or seizure disorder. I even had the newest studies done in 2009 to rule out ever having any seizure disorder where I now live in Houston, TX seeing one of the best neurologist and former psychiatrist and all test were negative. I wonder if the psychiatrist in Binghamton, NY at Wilson Mememorial Hospital feels about his mistake of taking a life (40 year old Mother) and making me an orphan at 19 even adding to the already severe depression I had been suffering having tried all available treatments which all fail me? We never sued as it wouldn't bring back my Mother. Forgive and move on with life with a positive, hopeful outlook that you will conquer your disorder one day and have the normal life.
Posted by SLS on January 5, 2012, at 10:41:36
In reply to Re: grief and major depression, posted by CaptainAmerica1967 on January 5, 2012, at 9:25:45
Hi Captain.
You answered my question thoroughly. Thanks.
- Scott
> Sorry, I missed this one Scott. I'm not sure what you mean by this question but I know that dynorphins work through Kappa receptors by Kappa binding dynorphins. One of the first symptoms I experienced at the age of 16 with anxiety, depression was a decreased libido and that might mean low dopamine as dopamine is the libido enhancing neurotransmitter besides PEA (phenylethylamine, short acting like in chocholate or long lasting increase of PEA by taking deprenyl-selegiline; also enhances brain longevity by increasing SOD, one of the bodies main antioxidants-rats lived almost twice as long on selegiline. I took selegiline while in college and couldn't foucs on studying as my libido was through the roof and would always be staring at various ladies in class instead of listening to the professor). Anyways, dynorphins decrease libido somehow via Kappa receptors binding. Oxytocin which is being studied as an antidepressant and is the cuddle love hormone (when in love) is associated somehow with dynorphins decreasing oxytocin via A negative feedback loop. Most of my life I took Nardil (I'm quite sure I lack GABA production produced in the nucleaus accumbens which also is the focus of deep brain stimulation and the area around Broadmanns 25-Helen Mayberg, MD, for depression, again an overactive brain) and MAOIs in general via the liver decrease testosterone production which further can cause depression and decreased libido (I think Nardil increases prolactin as well which inhibit libido) except until several year ago when I switched to Parnate which also decreases testosterone but the increase in dopamine from prevention of being broken down may counteract the liver decrease in testosterone. By the way, Buprenorphine and all opioids (heroin) decrease testosterone as well as lithium, haldol, marijuana, and barbiturates. My total tesstosterone (249-836) is very low normal being 252 (I'm 5' 11", 240 pounds, very low fat so little chance of conversion to estrogen and I lift weights and take 1000 IU of vitamin D which both are suppose to increase testosterone but mine is still low. It's really the "free testosterone" that has the benefits on the body; decrease c-reactive protein, cardiovascular disease, decrease in strokes, as well as decrease in osteoporosis, bone fracture, type 2 diabetes, metabolic disorder, sleep apnea, libido and other things like mood but most physicians including mine aren't very savvy when doing blood screening tests. OK, sorry, I got off the subject of dynorphins. So maybe Kappa antagonists block dynorphins as well to produce the antidepressant and antianxiety effect. I can say without a doubt that buprenorphine is a much better antianxiety medication than any type of benzodiazepine I've tried but maybe my anxiety is a subtype as describe in some literature on kappa antagonist. Lastly, I also first noticed feeling extremely warm and hot all the time like hot flashes but my thyroid tests were normal and I just looked this up and saw some correlation with body temperature and dynorphins.
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