Posted by SLS on June 14, 2005, at 17:02:21 [reposted on June 14, 2005, at 22:17:36 | original URL]
In reply to Re: Exercise for severe depression, posted by linkadge on June 14, 2005, at 16:01:58
Hi Linkadge.
> > atrophy and not neurodegeneration
> I don't think so. I think it is a truely a neurodegenerative process. Excess glutacortacoids can litterally punch holes in the brain through glutamate excitotoxitiy. Glutamate excitotoxicity kills the cell, no shrinkage. Much of Dr. Manjii's work into bipolar disorder is very suggestive of neurodengeration, and that's why he emphasizes preventitive neuroprotection. I'm not saying that atrophy cannot occur as well, but it is not all just atrophy
Unfortunately, I agree with you. My heart sank when I first read Manji's papers. He is brilliant. He has been doing ground-breaking work at the NIMH since I was there 13 years ago. Damned time. It never stops.
I am still betting on the plasticity of the brain to get me out of this mess.
You neglected my challenge. Why don't you go ahead and exercise your depression away?
The worst thing that can happen is you improve your conditioning. The best thing that can happen is that you cure yourself. It's a no lose situation. Go for it!
Keep a running diary thread the way others have done with specific medications. Give us updates as to the protocol you are employing and the results. I think that would be pretty cool.
- Scott
poster:SLS
thread:512835
URL: http://www.dr-bob.org/babble/health/20050411/msgs/512865.html