Posted by cache-monkey on May 7, 2005, at 17:40:25
In reply to Re: NIACINAMIDE for Anxiety, SP/PD » sdb, posted by Larry Hoover on April 27, 2005, at 9:20:20
Hi Larry,
I've been on benzos for the last couple of months. I've found that they really haven't done enough for my anxiety. They've been more sedating and depressiogenic than anxiolytic. I've been recently on Ativan and could feel it wearing off between doses. My pdoc wants me to discontinue, and I've been trying to work my way down from 3 mg.
I've been playing around with niacinamide since I heard about it on this board. I've noticed that in terms of my anxiety, nicanimide is far better than any of the benzos I've tried. I had been hoping to use it to withdraw from Ativan (I've seen reference to a study backing this idea) or perhaps switch over to it as a regular anxiolytic.
But, based on what you wrote here, I'm wondering if that leaves me with the same tolerance problem as with the benzos. Do you have any thoughts on this?
Also, do you happen to know the half-life of niacinamide? (If it's pretty short and the tolerance problem holds, then using it to taper probably isn't a great idea.)
Thanks,
cache-monkey<< Niacinamide and NAD both have binding affinity for GABA(A) receptors. Both change the conformation of the receptor itself, making it more sensitive to GABA. Niacinamide is a (mild) partial agonist, and I believe NAD is, as well.
As niacinamide readily crosses the blood-brain barrier, it can serve acutely as an anxiolytic. Long-term use would likely lead to down-regulation. Best keep niacinamide as an acute treatment, rather than use it as a maintenance vitamin. >>
poster:cache-monkey
thread:485434
URL: http://www.dr-bob.org/babble/alter/20050414/msgs/494949.html