Posted by karaS on October 24, 2004, at 23:12:55
In reply to Help needed with cholinergic drug reactions? » karaS, posted by tealady on October 24, 2004, at 18:23:35
> >In the last couple of years I have developed cholinergic urticaria (with all of its attendant implications for auto-immune response and inflammation). (It may have been there longer but been camouflaged by the small amount of antihistaminic tricyclic that I took to help with sleep.) I think that my hypersensitive dopamine autoreceptors are also a fairly recent phenomenon and I wonder if the two aren't related. I think that the autoreceptor problem is new because only recently have I noticed that I need to sleep about an hour or two after exercise
>
> Hi Kara, I know no posting...same here ..supposed to start studying.
> Just I wonder if we have something the same going on here.
>
> Firstly are you on any form of thyroid hormones at all..like T4, T3 or Armour and if so what?
> Here's why. I get lost with this, but my first reaction whan I started on Armour (which contains T3) but not on T4 meds was maybe something like a cholinergic drug drug for my bladder.
>
> I'm really lost here..the bladder nurse just told me a month oor so ago that my reaction were the same as happens occasionally for those taking cholinergic drugs.
>
> I can't seem to figure out what cholinergic drugs do? With me my bladder just retained urine..and I couldn't go..until the T3 (thyroid hormones) began to wear off and then I got a steady trickle for a day or so.
> I went to 2 docs at the time but both just put a question mark in my records and did the usual pretend I didn't visit them them..errr except that the bill payment was recorded <g>. Apparently what I should have done is go to emergency and get catherised..now I know grr
>
> So with all of this I'm trying to work out if acetylcholine, choline, or even say lecithin will
> have the same effect as cholinergic drugs??
> Really I'm so lost here??
>
> Is this what you mean? I really don't understand the terminology. What is meant by cholinergic?
>
> Also I'm lost with this "hypersensitive dopamine autoreceptors" too <g>.. If I say take some tyrosine I get a strong dopamine-like reaction maybe, like I can kinda "trip" on say 2g of tyrosine ..if that's what you mean ? I also get very tired after exercise, need to sleep for a day or two to feel good again..or doing anything actually <g>
>
> Jan
Hi Jan,I shouldn't be checking this board now but here I am.....
Cholinergic urticaria is a condition where your body becomes allergic to it's own sweat from overheating. When I exercise, after I've warmed up a bit, I start itching like crazy - like I could rip my flesh off it's so extreme. I've learned that it's an autoimmune response. I just noticed it within the last couple of years. I don't understand why they call it "cholinergic" or how choline fits into the picture. I would think it should be called "histaminic urticaria". Maybe someone else could shed some light here. I do have thyroid problems and I've taken both Armour and plain T4 but it doesn't have any impact on this condition. I don't think that our conditions are related at all. I do hope you get some relief with your situation though.
As for the hypersensitive dopamine autoreceptors, that's something I've just started learning about. Todd (King Vultan) on the main board explained it to me. I had some surprising paradoxical reactions to dopaminergic meds and supplements. They all put me to sleep. This is generally thought to be a result of super sensitive (or too many or too dense) dopamine receptors. When most people get certain areas of their brains flooded with dopamine, they react as you would generally expect from stimulants. Those of us with this problem have receptors that are working overtime. My very crude understanding of the situation is that these receptors serve as a feedback mechanism. They sense too much dopamine and pull it out of there quickly leaving you with too little and therefore, they put you to sleep. Since I have anergic depression, I have been counting on dopaminergic augmentation. It has left me rather desperately trying to understand it all and find a way (if possible) to treat it. At least I understand now why I have no motivation! Hope that helps you to understand it.
Ok, go study!
Kara
poster:karaS
thread:359642
URL: http://www.dr-bob.org/babble/alter/20041022/msgs/406840.html