Posted by tealady on October 21, 2004, at 19:57:21
In reply to Re: Supplements for brain fog? » raybakes, posted by raybakes on October 21, 2004, at 11:37:14
> retinoic acid inhibiting TSH is interesting, particularly as hypothyroid people don't activate vitamin A easily.
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> Retinoic acid inhibits in vivo thyroid-stimulating hormone secretion.
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> Coya R, Carro E, Mallo F, Dieguez C.
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> Department of Physiology, Faculty of Medicine, University of Santiago de Compostela, Spain.
>
> Retinoids are needed for normal growth and development. Retinoic acid (RA), an active metabolite of vitamin A, acts through nuclear receptors that belongs to the superfamily which also includes the T3 receptors and 1-25-dihydroxyvitamin D receptor. In order to assess whether RA is a regulator of in vivo thyroid-stimulating hormone (TSH) secretion, we studied the effect of RA administration on spontaneous basal TSH secretion and TSH responses to TRH in either euthyroid or hypothyroid rats. We found that rats treated with RA showed a decrease in spontaneous basal TSH levels and TSH responses to TRH. Similarly, RA administration to hypothyroid rats led to a decrease on TSH responses to TRH. Our data suggests that RA plays an important inhibitory role on in vivo secretion and this effect is unrelated to the thyroid status of the animals.
>Interesting Ray.
I would not have been surprised if you'd found VitD plays an important inhibitory role on TSH responses to TRH.
Logic here being on hotter days( supposedly stronger VitD in sun) you seem to need less T3..which also makes sense as you don't require as much energy to maintain body temperature at 37C..not that I ever get there!Nah, VItD and temperature are tooooo far unrelated. I wonder how temperature regulates TSH?
Is there any chemical type thing in our body that has to do with temperature..we must regulate somehow? My regulation of body temperature doesn't appear to function that well.
(decided I'm part ectotherm :))(I'm 33.5 and 34.5 today underarm, unless I get up above 36 my right underarm is usually 1 degree colder than left uderarm..strange no?)
But I've never thought about VitA.
Hmm I've no idea know what function VitA plays in our body come to think of it..Thanks, Jan
poster:tealady
thread:359642
URL: http://www.dr-bob.org/babble/alter/20040928/msgs/405647.html