Posted by linkadge on February 22, 2022, at 15:42:37
In reply to Re: Anyone try CBD?, posted by undopaminergic on February 21, 2022, at 8:01:04
>Cannabidiol has low affinity for the cannabinoid >CB1 and CB2 receptors, although it can act as an >antagonist of CB1/CB2 agonists despite this low >affinity.
Yeah, it may have some mixed agonist / antagonist effects depending on the endocannabinoid level. I remember reading that the anti-anxiety effects could be blocked (in mice) by CB1 antagonists. In some animal models too, it prolongs the synaptic effects of THC.
Linkadge
poster:linkadge
thread:1118679
URL: http://www.dr-bob.org/babble/20220128/msgs/1118723.html